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Literature summary extracted from

  • Prip-Buus, C.; Cohen, I.; Kohl, C.; Esser, V.; McGarry, J.D.; Girard, J.
    Topological and functional analysis of the rat liver carnitine palmitoyltransferase 1 expressed in Saccharomyces cerevisiae (1998), FEBS Lett., 429, 173-178.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.21 expression of L-CPT I in Saccharomyces cerevisiae, recombinant and native enzyme show the same biochemical properties Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.21 malonyl-CoA L-CPT I, recombinant enzyme from Saccharomyces cerevisiae is inhibited only in intact mitochondria, not as solubilized enzyme Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.21 mitochondrial outer membrane L-CPT I in outer membrane, native and recombinant in Saccharomyces cerevisiae Rattus norvegicus 5741
-
2.3.1.21 mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.21 acyl-CoA + L-carnitine Rattus norvegicus
-
 CoA + L-acylcarnitine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.21 Rattus norvegicus
-
 L-CPT I
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.21 liver L-CPT I Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.21 0.0013
-
 native L-CPT I in liver mitochondria Rattus norvegicus
2.3.1.21 0.0032
-
 mitochondrial fraction of recombinant Saccharomyces cerevisiae expressing L-CPT I Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.21 acyl-CoA + L-carnitine
-
 Rattus norvegicus CoA + L-acylcarnitine
-
 ?
2.3.1.21 palmitoyl-CoA + L-carnitine
-
 Rattus norvegicus CoA + L-palmitoylcarnitine
-
 ?