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Literature summary extracted from

  • Kerner, J.; Bieber, L.
    Isolation of a malonyl-CoA-sensitive CPT/beta-oxidation enzyme complex from heart mitochondria (1990), Biochemistry, 29, 4326-4334.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.21 malonyl-CoA CPT II not inhibited; mitochondrial isozyme CPT I, sensitivity against malonyl-CoA is mediated by a 86 kDa malonyl-CoA binding protein complexed with CPT and other proteins of the beta-oxidation, detergent and salt sensitive Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.21 additional information
-
 additional information
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.21 mitochondrion
-
 Bos taurus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.21 additional information
-
-
 Bos taurus
2.3.1.21 68000
-
 x * 68000, SDS-PAGE Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.21 acyl-CoA + L-carnitine Bos taurus
-
 CoA + L-acylcarnitine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.21 Bos taurus
-
 enzyme forms CPTi and CPTo
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.21 CPTo Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.21 heart
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.21 acyl-CoA + L-carnitine
-
 Bos taurus CoA + L-acylcarnitine
-
 ?
2.3.1.21 decanoyl-CoA + L-carnitine
-
 Bos taurus CoA + L-decanoylcarnitine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.21 ? x * 68000, SDS-PAGE Bos taurus
2.3.1.21 More CPTo and CPTi are associated with a complex that contains beta-oxidation enzymes Bos taurus