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Literature summary extracted from

  • Rahier, A.; Genot, J.C.; Schuber, F.; Benveniste, P.; Narula, A.S.
    Inhibition of S-adenosyl-L-methionine sterol-C-24-methyltransferase by analogues of a carbocationic ion high-energy intermediate. Structure activity relationships for C-25 heteroatoms (N, As, S) substituted triterpenoid derivatives (1984), J. Biol. Chem., 259, 15215-15223.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.142 (24R)-24-methyl-25,26,27-trisnor-24-dimethylamino-N-oxide cycloartenol
-
 Zea mays
2.1.1.142 (24R)-24-methyl-25-azacycloartenol
-
 Zea mays
2.1.1.142 (24R,S)-24-Ethyl-25-azacycloartenol
-
 Zea mays
2.1.1.142 (24R,S)-24-Methyl-25,26,27-trisnor-24-dimethylamino-N-oxide cycloartenol
-
 Zea mays
2.1.1.142 (24R,S)-24-Methyl-25,26,27-trisnor-24-dimethylsulfonium cycloartenol iodide
-
 Zea mays
2.1.1.142 (24R,S)-24-Methyl-25,26,27-trisnor-24-trimethylarsonium cycloartenol iodide
-
 Zea mays
2.1.1.142 (24R,S)-24-Methyl-25-azacycloartenol
-
 Zea mays
2.1.1.142 (24S)-24-methyl-25,26,27-trisnor-24-dimethylamino-N-oxide cycloartenol
-
 Zea mays
2.1.1.142 (24S)-24-methyl-25-azacycloartenol
-
 Zea mays
2.1.1.142 23-Azacholesterol
-
 Zea mays
2.1.1.142 24-Azacholesterol
-
 Zea mays
2.1.1.142 24-Azacycloartanyl acetate
-
 Zea mays
2.1.1.142 24-Methyl-25,26,27-trisnor-24-trimethylammonium cycloartenol iodide 24R and 24S isomer Zea mays
2.1.1.142 24-Methyl-25-azacycloartenol 24R and 24S isomer Zea mays
2.1.1.142 24-Oxo-25-azacycloartenol
-
 Zea mays
2.1.1.142 25,26,27-Trisnor-24-trimethylammonium cycloartenol iodide
-
 Zea mays
2.1.1.142 25-Azacholesterol
-
 Zea mays
2.1.1.142 25-Azacycloartenol
-
 Zea mays

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.142 microsome
-
 Zea mays
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.142 cycloartenol + S-adenosyl-L-methionine Zea mays cycloartenol is 4,4,14alpha-trimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol 24-methylenecycloartanol + S-adenosyl-L-homocysteine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.142 Zea mays
-
 corn
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.142 seedling
-
 Zea mays
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.142 cycloartenol + S-adenosyl-L-methionine cycloartenol is 4,4,14alpha-trimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol Zea mays 24-methylenecycloartanol + S-adenosyl-L-homocysteine
-
 ?
2.1.1.142 zymosterol + S-adenosyl-L-methionine
-
 Zea mays fecosterol + S-adenosyl-L-homocysteine
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.142 0.000015
-
 (24R)-24-methyl-25,26,27-trisnor-24-dimethylamino-N-oxide cycloartenol
-
 Zea mays
2.1.1.142 0.00002
-
 (24R,S)-24-Methyl-25-azacycloartenol
-
 Zea mays
2.1.1.142 0.00002
-
 (24R)-24-methyl-25-azacycloartenol
-
 Zea mays
2.1.1.142 0.000025
-
 (24R,S)-24-Methyl-25,26,27-trisnor-24-trimethylarsonium cycloartenol iodide
-
 Zea mays
2.1.1.142 0.00003
-
 25-Azacycloartenol
-
 Zea mays
2.1.1.142 0.00003
-
 24-Azacycloartanyl acetate
-
 Zea mays
2.1.1.142 0.00003
-
 (24S)-24-methyl-25-azacycloartenol
-
 Zea mays
2.1.1.142 0.000035
-
 24-Methyl-25,26,27-trisnor-24-trimethylammonium cycloartenol iodide
-
 Zea mays
2.1.1.142 0.000035
-
 25,26,27-Trisnor-24-trimethylammonium cycloartenol iodide
-
 Zea mays
2.1.1.142 0.000045
-
 25-Azacholesterol
-
 Zea mays
2.1.1.142 0.000045
-
 (24S)-24-methyl-25,26,27-trisnor-24-dimethylamino-N-oxide cycloartenol
-
 Zea mays
2.1.1.142 0.00005
-
 (24R,S)-24-Methyl-25,26,27-trisnor-24-dimethylsulfonium cycloartenol iodide
-
 Zea mays
2.1.1.142 0.000085
-
 (24R,S)-24-Ethyl-25-azacycloartenol
-
 Zea mays
2.1.1.142 0.00009
-
 23-Azacholesterol
-
 Zea mays
2.1.1.142 0.00017
-
 24-Oxo-25-azacycloartenol
-
 Zea mays
2.1.1.142 0.00018
-
 24-Azacholesterol
-
 Zea mays