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Literature summary extracted from

  • Hasne, M.P.; Lawrence, F.
    Characterization of prenylated protein methyltransferase in Leishmania (1999), Biochem. J., 342, 513-518.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.100 guanosine 5'-[gamma-thio]-triphosphate stimulation of carboxymethylation of endogenous substrates Leishmania donovani
2.1.1.100 additional information no increase in N-acetyl-S-(E,E)-farnesyl-L-cysteine methylation Leishmania donovani

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.100 methylthioadenosine 0.9 mM, 50% inhibition Leishmania donovani
2.1.1.100 S-adenosyl-L-homocysteine 0.025 mM; 50% inhibition Leishmania donovani
2.1.1.100 S-farnesyl thiosalicylic acid 0.05 mM, 50% inhibition Leishmania donovani
2.1.1.100 sinefungin 0.00002 mM; 50% inhibition, competitive vs. S-adenosyl-L-methionine Leishmania donovani

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.100 0.00013
-
 S-adenosyl-L-methionine
-
 Leishmania donovani
2.1.1.100 0.06
-
 N-acetyl-S-(E,E)-farnesyl-L-cysteine
-
 Leishmania donovani
2.1.1.100 0.166
-
 N-acetyl-S-geranylgeranyl-L-cysteine
-
 Leishmania donovani

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.100 Leishmania donovani
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.100 S-adenosyl-L-methionine + N-acetyl-S-geranylgeranyl-L-cysteine
-
 Leishmania donovani S-adenosyl-L-homocysteine + N-acetyl-S-geranylgeranyl-L-cysteine methyl ester
-
 ?
2.1.1.100 S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine
-
 Leishmania donovani S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
-
 ?
2.1.1.100 S-adenosylmethionine + N-acetyl-S-(E,E)-farnesyl-L-cysteine
-
 Leishmania donovani S-adenosylhomocysteine + N-acetyl-S-(E,E)-farnesyl-L-cysteine methyl ester
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.100 6.5 8
-
 Leishmania donovani