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Literature summary extracted from

  • Bello, A.R.; Nare, B.; Freedman, D.; Hardy, L.; Beverly, S.M.
    PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major (1994), Proc. Natl. Acad. Sci. USA, 91, 11442-11446.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.5.1.33 expression in Escherichia coli Leishmania major

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.33 additional information
-
 Leishmania major

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.1.33 additional information Leishmania major primary enzyme mediating pteridine salvage ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.33 Leishmania major
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.33 Biopterin + NADPH activity with NADH is less than 5% of the activity with NADPH Leishmania major 5,6,7,8-Tetrahydrobiopterin + NADP+
-
 ?
1.5.1.33 Dihydrobiopterin + NADPH
-
 Leishmania major ?
-
 ?
1.5.1.33 Dihydrofolate + NADPH
-
 Leishmania major 5,6,7,8-Tetrahydrofolate + NADP+
-
 ?
1.5.1.33 folate + NADPH
-
 Leishmania major 5,6,7,8-tetrahydrofolate + NADP+
-
 ?
1.5.1.33 additional information no activity with quinoid dihydrobiopterin Leishmania major ?
-
 ?
1.5.1.33 additional information primary enzyme mediating pteridine salvage Leishmania major ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.5.1.33 4.7
-
 biopterin as substrate Leishmania major
1.5.1.33 4.7
-
 dihydrobiopterin as substrate Leishmania major
1.5.1.33 6
-
 dihydrofolate as substrate Leishmania major
1.5.1.33 6
-
 folate as substrate Leishmania major

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.33 NADPH dependent on Leishmania major