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Literature summary extracted from
- Mechanism of action of the flavoenzyme lactate oxidase (1972), J. Biol. Chem., 247, 8097-8106.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.13.12.4 | chloride | - |
Mycolicibacterium smegmatis |  |
| 1.13.12.4 | nitrate | - |
Mycolicibacterium smegmatis | |
| 1.13.12.4 | phosphate | competitive inhibitor | Mycolicibacterium smegmatis | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.13.12.4 | 11.3 | - |
L-alpha-hydroxy-beta-methylvalerate | - |
Mycolicibacterium smegmatis | |
| 1.13.12.4 | 22.3 | - |
(S)-lactate | - |
Mycolicibacterium smegmatis | |
| 1.13.12.4 | 25 | - |
L-2-hydroxyisovalerate | - |
Mycolicibacterium smegmatis | |
| 1.13.12.4 | 50 | - |
beta-phenyl-(S)-lactate | - |
Mycolicibacterium smegmatis | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.12.4 | (S)-lactate + O2 | Mycolicibacterium smegmatis | - |
acetate + CO2 + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.13.12.4 | Mycolicibacterium smegmatis | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.12.4 | (S)-lactate + O2 | - |
Mycolicibacterium smegmatis | acetate + CO2 + H2O | - |
? | |
| 1.13.12.4 | 2-hydroxy-3-methylvalerate + O2 | - |
Mycolicibacterium smegmatis | ? | - |
? | |
| 1.13.12.4 | 2-hydroxyisovalerate + O2 | - |
Mycolicibacterium smegmatis | ? | - |
? | |
| 1.13.12.4 | beta-phenyl-(S)-lactate + O2 | - |
Mycolicibacterium smegmatis | ? | - |
r | |
| 1.13.12.4 | beta-phenyllactate + O2 | - |
Mycolicibacterium smegmatis | ? | - |
? | |
| 1.13.12.4 | L-2-hydroxyisovalerate + O2 | - |
Mycolicibacterium smegmatis | ? | - |
r | |
| 1.13.12.4 | L-alpha-hydroxy-beta-methylvalerate + O2 | - |
Mycolicibacterium smegmatis | ? | - |
r | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.13.12.4 | 0.4 | - |
nitrate | - |
Mycolicibacterium smegmatis | |
| 1.13.12.4 | 10 | 16 | phosphate | - |
Mycolicibacterium smegmatis | |
| 1.13.12.4 | 50 | - |
chloride | - |
Mycolicibacterium smegmatis | |
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Release 2023.1 (January 2023)
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