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Literature summary extracted from
- Desacetoxycephalosporin C synthetase: importance of order of cofactor/reactant addition (1984), Enzyme Microb. Technol., 6, 402-404.
No PubMed abstract available
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.20.1 | additional information | best activity is obtained by adding to the enzyme a mixture of ATP, Fe2+, and ascorbate, followed by addition of 2-oxoglutarate, and then penicillin N. Simultaneous addition of ATP, Fe2+, and ascorbate is preferable to sequential addition | Acremonium chrysogenum |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.20.1 | additional information | when 2-oxoglutarate is added to the enzyme before the mixture of ATP, Fe2+ and ascobate activity is only about 40% of the reaction | Acremonium chrysogenum |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.20.1 | Acremonium chrysogenum | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.14.20.1 | - |
Acremonium chrysogenum |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.20.1 | penicillin N + 2-oxoglutarate + O2 | almost absolute requirement for 2-oxoglutarate | Acremonium chrysogenum | deacetoxycephalosporin C + succinate + CO2 + H2O | - |
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Release 2023.1 (January 2023)
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