EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.14.14.17 | microsome | - |
Rattus norvegicus | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.17 | squalene + electron donor + O2 | Rattus norvegicus | may be rate-limiting step in cholesterol biosynthesis in non-cholesterogenic tissues | (S)-squalene-2,3-epoxide + oxidized electron donor + H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.14.17 | Rattus norvegicus | - |
- |
- |
5.4.99.7 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.14.17 | liver | - |
Rattus norvegicus | - |
1.14.14.17 | additional information | very low activity in non-cholesterogenic tissues: brain, muscle, lung, placenta, kidney | Rattus norvegicus | - |
5.4.99.7 | brain | - |
Rattus norvegicus | - |
5.4.99.7 | kidney | - |
Rattus norvegicus | - |
5.4.99.7 | liver | - |
Rattus norvegicus | - |
5.4.99.7 | lung | - |
Rattus norvegicus | - |
5.4.99.7 | additional information | the enzyme is present in all cholesterogenic and non-cholesterogenic tissues. The level of lanosterol synthase is very low in non-cholesterogenic tissues | Rattus norvegicus | - |
5.4.99.7 | muscle | - |
Rattus norvegicus | - |
5.4.99.7 | placenta | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.17 | squalene + electron donor + O2 | may be rate-limiting step in cholesterol biosynthesis in non-cholesterogenic tissues | Rattus norvegicus | (S)-squalene-2,3-epoxide + oxidized electron donor + H2O | - |
? | |
1.14.14.17 | squalene + NAD(P)H + O2 | - |
Rattus norvegicus | (S)-squalene-2,3-epoxide + NADP+ + H2O | - |
? | |
5.4.99.7 | (S)-squalene-2,3-epoxide | - |
Rattus norvegicus | Lanosterol | - |
? |