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Literature summary extracted from
- Rat brain aspartate beta-decarboxylase. A comparative study with the liver enzyme (1985), Neurochem. Int., 7, 351-355.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.12 | Ser | acticates liver enzyme, competitively inhibits kidney and brain enzyme | Rattus norvegicus |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.12 | Ala | liver enzyme | Rattus norvegicus | |
| 4.1.1.12 | Aminooxyacetate | - |
Rattus norvegicus | |
| 4.1.1.12 | beta-Ala | liver enzyme | Rattus norvegicus | |
| 4.1.1.12 | Cys | liver enzyme | Rattus norvegicus | |
| 4.1.1.12 | Gln | liver enzyme | Rattus norvegicus | |
| 4.1.1.12 | Glu | liver enzyme | Rattus norvegicus | |
| 4.1.1.12 | Ser | activates liver enzyme, competitively inhibits kidney and brain enzyme | Rattus norvegicus | |
| 4.1.1.12 | Val | weak, liver enzyme | Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.1.1.12 | 1.3 | - |
L-Asp | brain enzyme | Rattus norvegicus | |
| 4.1.1.12 | 3.5 | - |
L-Asp | liver and kidney enzyme | Rattus norvegicus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.12 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.1.1.12 | brain | highest activity in the cortex, lowest activity in the striatum and hippocampus | Rattus norvegicus | - |
| 4.1.1.12 | kidney | - |
Rattus norvegicus | - |
| 4.1.1.12 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.12 | L-Asp | - |
Rattus norvegicus | L-Ala + CO2 | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.12 | 7.1 | 7.4 | - |
Rattus norvegicus |
| 4.1.1.12 | 7.4 | - |
- |
Rattus norvegicus |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.12 | 5.7 | 8.1 | about 60% of maximal activity at pH 5.7 and pH 8.1 | Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.12 | pyridoxal 5'-phosphate | firmly bound cofactor | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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