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Literature summary extracted from

  • Wittwer, A.J.; Wagner, C.
    Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Purification and folate-binding characteristics (1981), J. Biol. Chem., 256, 4102-4108.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.5.8.3 mitochondrion
-
 Rattus norvegicus 5739
-
1.5.8.4 mitochondrion
-
 Rattus norvegicus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.5.8.3 92000 105000 SDS-PAGE Rattus norvegicus
1.5.8.4 90000
-
 x * 90000, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.8.3 sarcosine + acceptor + H2O Rattus norvegicus acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate glycine + formaldehyde + reduced acceptor
-
 ?
1.5.8.4 N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor Rattus norvegicus during the reaction tightly bound tetrahydropteroylpentaglutamate is converted to 5,10-methylene tetrahydropteroylpentaglutamate sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor
-
 ?
1.5.8.4 N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor Rattus norvegicus reaction of the choline degradation pathway sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.8.3 Rattus norvegicus
-
-
-
1.5.8.4 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.5.8.3
-
 Rattus norvegicus
1.5.8.4
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.8.3 liver
-
 Rattus norvegicus
-
1.5.8.4 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.8.3 sarcosine + acceptor + H2O acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate Rattus norvegicus glycine + formaldehyde + reduced acceptor
-
 ?
1.5.8.4 N,N-dimethylglycine + acceptor + H2O acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate Rattus norvegicus sarcosine + formaldehyde + reduced acceptor
-
 ?
1.5.8.4 N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor during the reaction tightly bound tetrahydropteroylpentaglutamate is converted to 5,10-methylene tetrahydropteroylpentaglutamate Rattus norvegicus sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor
-
 ?
1.5.8.4 N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor reaction of the choline degradation pathway Rattus norvegicus sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor
-
 ?

Subunits

EC Number Subunits Comment Organism
1.5.8.4 ? x * 90000, SDS-PAGE Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.8.3 FAD covalent bound FAD linked via 8a-position of the isoalloxazin ring to the imidazole N(3) of a histidine residue, structural homology between the amino acid sequence of the flavin-peptides Rattus norvegicus
1.5.8.3 tetrahydrofolate
-
 Rattus norvegicus
1.5.8.4 FAD covalently bound Rattus norvegicus
1.5.8.4 Tetrahydropteroylpentaglutamate
-
 Rattus norvegicus