EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.3.1.12 | 4-hydroxymercuribenzoate | - |
Pseudomonas flexibilis | |
1.3.1.12 | L-tyrosine | - |
Pseudomonas flexibilis | |
1.3.1.43 | L-tyrosine | competitive inhibition | Pseudomonas flexibilis |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.3.1.12 | 0.045 | 0.09 | prephenate | - |
Pseudomonas flexibilis | |
1.3.1.12 | 0.45 | - |
NAD+ | - |
Pseudomonas flexibilis | |
1.3.1.43 | 0.41 | - |
NAD+ | - |
Pseudomonas flexibilis | |
1.3.1.43 | 0.66 | - |
L-arogenate | - |
Pseudomonas flexibilis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.1.12 | prephenate + NAD+ | Pseudomonas flexibilis | biosynthesis of L-tyrosine | 4-hydroxyphenylpyruvate + NADH + CO2 | - |
? | |
1.3.1.43 | L-arogenate + NAD+ | Pseudomonas flexibilis | - |
L-tyrosine + NADH + CO2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.3.1.12 | Pseudomonas flexibilis | - |
- |
- |
1.3.1.43 | Pseudomonas flexibilis | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.3.1.12 | copurification with arogenate dehydrogenase | Pseudomonas flexibilis |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.1.12 | prephenate + NAD+ | - |
Pseudomonas flexibilis | 4-hydroxyphenylpyruvate + NADH + CO2 | - |
? | |
1.3.1.12 | prephenate + NAD+ | biosynthesis of L-tyrosine | Pseudomonas flexibilis | 4-hydroxyphenylpyruvate + NADH + CO2 | - |
? | |
1.3.1.43 | L-arogenate + NAD(P)+ | - |
Pseudomonas flexibilis | L-tyrosine + NAD(P)H + CO2 | - |
? | |
1.3.1.43 | L-arogenate + NAD+ | - |
Pseudomonas flexibilis | L-tyrosine + NADH + CO2 | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.3.1.43 | 37 | - |
assay at | Pseudomonas flexibilis |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.3.1.12 | additional information | NADP+ cannot substitute for NAD+ | Pseudomonas flexibilis | |
1.3.1.12 | NAD+ | - |
Pseudomonas flexibilis | |
1.3.1.43 | NAD+ | - |
Pseudomonas flexibilis |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.3.1.12 | 0.017 | - |
L-tyrosine | with prephenate as variable substrate | Pseudomonas flexibilis | |
1.3.1.12 | 0.02 | - |
L-tyrosine | with NAD+ as variable substrate | Pseudomonas flexibilis | |
1.3.1.43 | 0.016 | - |
L-tyrosine | competitive inhibition | Pseudomonas flexibilis |