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Literature summary extracted from

  • Vojtechova, M.; Hanson, A.D.; Munoz-Clares, R.A.
    Betaine-aldehyde dehydrogenase from amaranth leaves efficiently catalyzes the NAD-dependent oxidation of dimethylsulfoniopropionaldehyde to dimethylsulfoniopropionate (1997), Arch. Biochem. Biophys., 337, 81-88.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.8 3-dimethylsulfoniopropionaldehyde at high concentrations Amaranthus hypochondriacus
1.2.1.8 AMP
-
 Amaranthus hypochondriacus
1.2.1.8 choline
-
 Amaranthus hypochondriacus
1.2.1.8 NADH
-
 Amaranthus hypochondriacus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.8 0.0027
-
 3-dimethylsulfoniopropionaldehyde
-
 Amaranthus hypochondriacus
1.2.1.8 0.011
-
 NAD+ reaction with betaine aldehyde Amaranthus hypochondriacus
1.2.1.8 0.0133
-
 NAD+ reaction with 3-dimethylsulfoniopropionaldehyde Amaranthus hypochondriacus
1.2.1.8 0.0937
-
 Betaine aldehyde
-
 Amaranthus hypochondriacus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.8 betaine aldehyde + NAD+ + H2O Amaranthus caudatus
-
 betaine + NADH
-
 ?
1.2.1.8 betaine aldehyde + NAD+ + H2O Amaranthus hypochondriacus enzyme catalyzes the final irreversible step in the synthesis of glycine betaine betaine + NADH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.8 Amaranthus caudatus
-
-
-
1.2.1.8 Amaranthus hypochondriacus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.8
-
 Amaranthus hypochondriacus

Reaction

EC Number Reaction Comment Organism Reaction ID
1.2.1.8 betaine aldehyde + NAD+ + H2O = betaine + NADH + 2 H+ steady-state ordered bi bi or rapid equilibrium mechanism Amaranthus hypochondriacus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.8 leaf
-
 Amaranthus hypochondriacus
-
1.2.1.8 leaf
-
 Amaranthus caudatus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.8 3-dimethylsulfoniopropionaldehyde + NAD+ + O2 steady state bi bi mechanism with ordered addition of substrates and random release of products Amaranthus hypochondriacus 3-dimethylsulfoniopropionate + NADH
-
 ir
1.2.1.8 4-aminobutyraldehyde + NAD+ + H2O
-
 Amaranthus hypochondriacus 4-aminobutyrate + NADH
-
 ?
1.2.1.8 betaine aldehyde + NAD+ + H2O
-
 Amaranthus hypochondriacus betaine + NADH
-
 ir
1.2.1.8 betaine aldehyde + NAD+ + H2O
-
 Amaranthus caudatus betaine + NADH
-
 ?
1.2.1.8 betaine aldehyde + NAD+ + H2O enzyme catalyzes the final irreversible step in the synthesis of glycine betaine Amaranthus hypochondriacus betaine + NADH
-
 ?