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Literature summary extracted from

  • Schuman, M.; Massey, V.
    Effect of anions on the catalytic activity of pig liver glycolic acid oxidase (1971), Biochim. Biophys. Acta, 227, 521-537.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.3.15 arsenate increasing activity up to 0.1 M, inhibition of ferricyanide-linked assay above 0.1 M Sus scrofa
1.1.3.15 phosphate increasing activity up to 0.1 M, inhibition of ferricyanide-linked assay above 0.1 M Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.3.15 acetate
-
 Sus scrofa
1.1.3.15 arsenate inhibition of glycolate-ferricyanide or glyoxylate-ferricyanide assay above 0.1 M Sus scrofa
1.1.3.15 Butyrate
-
 Sus scrofa
1.1.3.15 glycolate inhibition above 1.7 mM Sus scrofa
1.1.3.15 Heptanoate
-
 Sus scrofa
1.1.3.15 hexanoate
-
 Sus scrofa
1.1.3.15 malonate
-
 Sus scrofa
1.1.3.15 oxalate
-
 Sus scrofa
1.1.3.15 phosphate inhibition of glycolate-ferricyanide or glyoxylate-ferricyanide assay above 0.1 M Sus scrofa
1.1.3.15 propionate
-
 Sus scrofa
1.1.3.15 succinate
-
 Sus scrofa
1.1.3.15 valerate
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.3.15 0.28
-
 dichlorophenolindophenol cosubstrate: glycolate Sus scrofa
1.1.3.15 0.42
-
 glycolate cosubstrate: 2,6-dichlorophenolindophenol Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.3.15 glycolate + O2 Sus scrofa
-
 glyoxylate + H2O2
-
 ?
1.1.3.15 glyoxylate + O2 Sus scrofa
-
 ? + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.3.15 Sus scrofa
-
 pig
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.3.15 liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.3.15 glycolate + 2,6-dichlorophenolindophenol
-
 Sus scrofa glyoxylate + reduced 2,6-dichlorophenolindophenol
-
 ?
1.1.3.15 glycolate + ferricyanide
-
 Sus scrofa glyoxylate + ferrocyanide
-
 ?
1.1.3.15 glycolate + O2
-
 Sus scrofa glyoxylate + H2O2
-
 ?
1.1.3.15 glyoxylate + 2,6-dichlorophenolindophenol
-
 Sus scrofa ? + reduced 2,6-dichlorophenolindophenol
-
 ?
1.1.3.15 glyoxylate + ferricyanide
-
 Sus scrofa ? + ferrocyanide
-
 ?
1.1.3.15 glyoxylate + O2
-
 Sus scrofa ? + H2O2
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.3.15 FMN
-
 Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.3.15 additional information
-
 additional information straight-chain monocarboxylic acids are non-competitive inhibitors with either glycolate or glyoxylate as substrates, dicarboxylic acids are competitive inhibitors with glycolate as substrate, but non-competitive inhibitors for glyoxylate as substrate Sus scrofa
1.1.3.15 0.092
-
 Heptanoate non-competitive, glycolate oxidation Sus scrofa
1.1.3.15 0.3
-
 hexanoate non-competitive, glycolate oxidation Sus scrofa
1.1.3.15 0.44
-
 oxalate competitive, glycolate oxidation, non-competitive for glyoxylate oxidation Sus scrofa
1.1.3.15 1.2
-
 valerate non-competitive, glyoxylate reduction Sus scrofa
1.1.3.15 1.3
-
 valerate non-competitive, glycolate oxidation Sus scrofa
1.1.3.15 3.6
-
 Butyrate non-competitive, glycolate oxidation Sus scrofa
1.1.3.15 8.2
-
 malonate non-competitive, glyoxylate reduction Sus scrofa
1.1.3.15 9.2
-
 malonate competitive, glycolate oxidation Sus scrofa
1.1.3.15 9.5
-
 propionate non-competitive, glycolate oxidation Sus scrofa
1.1.3.15 14
-
 succinate competitive, glycolate oxidation Sus scrofa
1.1.3.15 17
-
 propionate non-competitive, glyoxylate reduction Sus scrofa
1.1.3.15 37
-
 acetate non-competitive, glycolate oxidation Sus scrofa
1.1.3.15 48
-
 acetate non-competitive, glyoxylate reduction Sus scrofa