Literature summary extracted from

Reingold, D.F.; Kawasaki, A.; Needleman, P.
A novel prostaglandin 11-keto reductase found in rabbit liver (1981), Biochim. Biophys. Acta, 659, 179-188.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
1.1.1.188	imidazole	in vitro stimulation of prostaglandin F2alpha and D2 production	Oryctolagus cuniculus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.1.1.188	indomethacin	at 0.005 mg/ml in vivo inhibition of prostaglandin formation	Oryctolagus cuniculus

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
1.1.1.188	0.2	-	Prostaglandin D2	-	Oryctolagus cuniculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.188	Oryctolagus cuniculus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.188	(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH	-	Oryctolagus cuniculus	(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+	-	?

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
1.1.1.188	37	-	assay at	Oryctolagus cuniculus

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.1.1.188	NADH	less effective than NADPH	Oryctolagus cuniculus

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Release 2023.1 (January 2023)