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Literature summary extracted from

  • Frere, J.M.; Kelly, J.A.; Klein, D.; Ghuysen, J.M.
    delta 2- and delta 3-Cephalosporins, penicillinate and 6-unsubstituted penems. Intrinsic reactivity and interaction with beta-lactamases and D-alanyl-D-alanine-cleaving serine peptidases (1982), Biochem. J., 203, 223-234.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.16.4 2-Methylpenem
-
 Streptomyces sp.
3.4.16.4 2-Phenylpenem
-
 Streptomyces sp.
3.4.16.4 beta-lactams
-
 Streptomyces sp.
3.4.16.4 Delta2-(and Delta3)-Deacetoxy-7-phenylacetamidocephalosporanates
-
 Streptomyces sp.
3.4.16.4 Penicillanate
-
 Streptomyces sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.16.4 UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine Streptomyces sp.
-
 ?
-
 ?
3.4.16.4 UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine Streptomyces sp. R39
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.16.4 Streptomyces sp.
-
 R61
-
3.4.16.4 Streptomyces sp.
-
 R39
-
3.4.16.4 Streptomyces sp. R39
-
 R39
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.16.4 Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-D-Ala + H2O
-
 Streptomyces sp. Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala + D-alanine
-
 ?
3.4.16.4 Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala-D-Ala + H2O
-
 Streptomyces sp. R39 Nalpha,Nepsilon-diacetyl-L-Lys-D-Ala + D-alanine
-
 ?
3.4.16.4 UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine
-
 Streptomyces sp. ?
-
 ?
3.4.16.4 UDP-N-acetyl-muramyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine
-
 Streptomyces sp. R39 ?
-
 ?
3.4.16.4 UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine + H2O
-
 Streptomyces sp. UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanine + D-alanine
-
 ?
3.4.16.4 UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanyl-D-alanine + H2O
-
 Streptomyces sp. R39 UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-mesodiaminopimelyl-D-alanine + D-alanine
-
 ?