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Literature summary extracted from

  • Viola, F.; Brusa, P.; Balliano, G.; Ceruti, M.; Boutaud, O.; Schuber, F.; Cattel, L.
    Inhibition of 2,3-oxidosqualene cyclase and sterol biosynthesis by 10- and 19-azasqualene derivatives (1995), Biochem. Pharmacol., 50, 787-796.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.4.99.7 (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
-
 Candida albicans
5.4.99.7 (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
-
 Homo sapiens
5.4.99.7 (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
-
 Rattus norvegicus
5.4.99.7 (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
-
 Saccharomyces cerevisiae
5.4.99.7 (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
-
 Sus scrofa
5.4.99.7 (6Z)-10-aza-10,11-dihydrosqualene-2,3-epoxide poor Sus scrofa
5.4.99.7 19-Aza-18,19,22,3-tetrahydrosqualene-2,3-epoxide
-
 Candida albicans
5.4.99.7 19-Aza-18,19,22,3-tetrahydrosqualene-2,3-epoxide
-
 Homo sapiens
5.4.99.7 19-Aza-18,19,22,3-tetrahydrosqualene-2,3-epoxide
-
 Rattus norvegicus
5.4.99.7 19-Aza-18,19,22,3-tetrahydrosqualene-2,3-epoxide
-
 Saccharomyces cerevisiae
5.4.99.7 19-Aza-18,19,22,3-tetrahydrosqualene-2,3-epoxide noncompetitive Sus scrofa
5.4.99.7 19-Aza-18,19,22,3-tetrahydrosqualene-2,3-epoxide N-oxide
-
 Candida albicans
5.4.99.7 19-Aza-18,19,22,3-tetrahydrosqualene-2,3-epoxide N-oxide
-
 Homo sapiens
5.4.99.7 19-Aza-18,19,22,3-tetrahydrosqualene-2,3-epoxide N-oxide
-
 Saccharomyces cerevisiae
5.4.99.7 19-Aza-18,19,22,3-tetrahydrosqualene-2,3-epoxide N-oxide poor, competitive Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.7 Candida albicans
-
-
-
5.4.99.7 Homo sapiens
-
-
-
5.4.99.7 Rattus norvegicus
-
-
-
5.4.99.7 Saccharomyces cerevisiae
-
-
-
5.4.99.7 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.4.99.7 liver
-
 Rattus norvegicus
-
5.4.99.7 liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.7 (S)-squalene-2,3-epoxide
-
 Homo sapiens Lanosterol
-
 ?
5.4.99.7 (S)-squalene-2,3-epoxide
-
 Rattus norvegicus Lanosterol
-
 ?
5.4.99.7 (S)-squalene-2,3-epoxide
-
 Sus scrofa Lanosterol
-
 ?
5.4.99.7 (S)-squalene-2,3-epoxide
-
 Saccharomyces cerevisiae Lanosterol
-
 ?
5.4.99.7 (S)-squalene-2,3-epoxide
-
 Candida albicans Lanosterol
-
 ?