BRENDA - Enzyme Database

Differential inhibition of fungal oxidosqualene cyclase by 6E and 6Z isomers of 2,3-epoxy-10-aza-10,11-dihydrosqualene

Balliano, G.; Milla, P.; Ceruti, M.; Viola, F.; Carrano, L.; Cattel, L.; FEBS Lett. 320, 203-206 (1993)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.4.99.7
2,3-Epoxy-10-aza-10,11-dehydrosqualene
6E isomer strongly inhibits enzyme in both cell cultures and microsomes; weak inhibition by 6Z isomer
Candida albicans
5.4.99.7
2,3-Epoxy-10-aza-10,11-dehydrosqualene
6E isomer strongly inhibits enzyme in both cell cultures and microsomes; 6Z isomer has no effect on microsomal enzyme
Saccharomyces cerevisiae
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.4.99.7
microsome
-
Saccharomyces cerevisiae
-
-
5.4.99.7
microsome
-
Candida albicans
-
-
Organism
EC Number
Organism
UniProt
Commentary
Textmining
5.4.99.7
Candida albicans
-
-
-
5.4.99.7
Saccharomyces cerevisiae
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.4.99.7
cell culture
-
Candida albicans
-
5.4.99.7
cell culture
-
Saccharomyces cerevisiae
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
5.4.99.7
(S)-squalene-2,3-epoxide
-
3591
Saccharomyces cerevisiae
Lanosterol
-
3591
Saccharomyces cerevisiae
-
5.4.99.7
(S)-squalene-2,3-epoxide
-
3591
Candida albicans
Lanosterol
-
3591
Candida albicans
-
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.4.99.7
2,3-Epoxy-10-aza-10,11-dehydrosqualene
6E isomer strongly inhibits enzyme in both cell cultures and microsomes; weak inhibition by 6Z isomer
Candida albicans
5.4.99.7
2,3-Epoxy-10-aza-10,11-dehydrosqualene
6E isomer strongly inhibits enzyme in both cell cultures and microsomes; 6Z isomer has no effect on microsomal enzyme
Saccharomyces cerevisiae
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.4.99.7
microsome
-
Saccharomyces cerevisiae
-
-
5.4.99.7
microsome
-
Candida albicans
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.4.99.7
cell culture
-
Candida albicans
-
5.4.99.7
cell culture
-
Saccharomyces cerevisiae
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
5.4.99.7
(S)-squalene-2,3-epoxide
-
3591
Saccharomyces cerevisiae
Lanosterol
-
3591
Saccharomyces cerevisiae
-
5.4.99.7
(S)-squalene-2,3-epoxide
-
3591
Candida albicans
Lanosterol
-
3591
Candida albicans
-