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Literature summary extracted from
- Stabilizing effect of ethyleneglycol on deoxycytidylate deaminase in relation to thermal and ultraviolet inactivation (1975), Dokl. Bolg. Akad. Nauk, 28, 241-244.
No PubMed abstract available
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 3.5.4.12 | 2-mercaptoethanol stabilizes | Mus musculus |
| 3.5.4.12 | dCTP or glycerol stabilize | Mus musculus |
| 3.5.4.12 | ethyleneglycol, 20%, stabilizes against thermal and UV inactivation and denaturation factors with different mechanism of action | Mus musculus |
| 3.5.4.12 | glycerol stabilizes | Mus musculus |
| 3.5.4.12 | some free nucleotides, most effective dCTP, stabilize | Mus musculus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.4.12 | dCMP + H2O | Mus musculus | one of the regulatory enzymes of DNA biosynthesis | dUMP + NH3 | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.4.12 | Mus musculus | - |
Ehrlich's ascites tumor cells and various gastrointestinal tumors | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.5.4.12 | partial, Ehrlich's ascites tumor cells | Mus musculus |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 3.5.4.12 | dCMP + H2O = dUMP + NH3 | highly regulated allosteric enzyme | Mus musculus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.4.12 | dCMP + H2O | - |
Mus musculus | dUMP + NH3 | - |
? | |
| 3.5.4.12 | dCMP + H2O | one of the regulatory enzymes of DNA biosynthesis | Mus musculus | dUMP + NH3 | - |
? | |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.5.4.12 | additional information | - |
ethyleneglycol stabilizes against thermal and UV inactivation | Mus musculus |
| 3.5.4.12 | 43 | - |
in the presence of ethyleneglycol: 100% stable | Mus musculus |
| 3.5.4.12 | 50 | - |
ethyleneglycol stabilizes against thermal inactivation, when temperature increases to 50°C, leads to certain increase in specific activity | Mus musculus |
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Release 2023.1 (January 2023)
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