EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.5.1.3 | additional information | no activation by ATP, ADP, phosphate or arsenate | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.5.1.3 | cytoplasm | - |
Rattus norvegicus | 5737 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.5.1.3 | additional information | no requirement for Mg2+ or Mn2+ for formation of hydroxamate | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.1.3 | 2-oxoglutaramate + H2O | Rattus norvegicus | alpha-ketoglutaramate | 2-oxoglutarate + NH3 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.1.3 | Rattus norvegicus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.5.1.3 | partial | Rattus norvegicus |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
3.5.1.3 | a monoamide of a dicarboxylate + H2O = a dicarboxylate + NH3 | acyl-enzyme mechanism | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.5.1.3 | kidney | - |
Rattus norvegicus | - |
3.5.1.3 | liver | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.1.3 | 2-oxoglutaramate + H2O | best substrate | Rattus norvegicus | 2-oxoglutarate + NH3 | - |
? | |
3.5.1.3 | 2-oxoglutaramate + H2O | alpha-ketoglutaramate | Rattus norvegicus | 2-oxoglutarate + NH3 | - |
? | |
3.5.1.3 | 2-oxoglutaramate + hydroxylamine | alpha-ketoglutaramate | Rattus norvegicus | 2-oxoglutaryl hydroxamate + NH3 | - |
? | |
3.5.1.3 | 2-oxosuccinamate + H2O | alpha-ketosuccinamate | Rattus norvegicus | 2-oxosuccinate + NH3 | - |
? | |
3.5.1.3 | 2-oxosuccinamate + H2O | no formation of hydroxamate from alpha-ketosuccinamate | Rattus norvegicus | 2-oxosuccinate + NH3 | - |
? | |
3.5.1.3 | caproamide + H2O | no hydroxamte formation | Rattus norvegicus | caproic acid + NH3 | - |
? | |
3.5.1.3 | glutaramate + H2O | - |
Rattus norvegicus | glutarate + NH3 | - |
? | |
3.5.1.3 | glutaramate + hydroxylamine | amidase activity, hydrolysis proceeds at a slower rate than formation of glutaryl hydroxamate in the presence of hydroxylamine | Rattus norvegicus | glutaryl hydroxamate + NH3 | - |
? | |
3.5.1.3 | glutarate + hydroxylamine | at pH 5, not at pH 7 | Rattus norvegicus | glutaryl hydroxamate | - |
? | |
3.5.1.3 | L-isoasparagine + H2O | poor substrate | Rattus norvegicus | L-aspartate + NH3 | - |
? | |
3.5.1.3 | L-isoglutamine + H2O | poor substrate | Rattus norvegicus | L-glutamate + NH3 | - |
? | |
3.5.1.3 | L-leucine amide + H2O | no hydroxamte formation | Rattus norvegicus | L-Leu + NH3 | - |
? | |
3.5.1.3 | L-phenylalanine amide + H2O | poor substrate, 12% compared with alpha-ketoglutaramate | Rattus norvegicus | L-Phe + NH3 | - |
? | |
3.5.1.3 | additional information | substrate specificity | Rattus norvegicus | ? | - |
? | |
3.5.1.3 | additional information | catalyzes hydrolysis and transfer reactions, enzyme-dicarboxylic acid complex may react either with H2O or hydroxylamine | Rattus norvegicus | ? | - |
? | |
3.5.1.3 | additional information | glutamine, acetamide, propionamide, butyramide, isobutyramide, isovaleramide, oxamate, malonamate, adipamate, oxamide, adipamide, alpha-ketoadipamate, alpha-keto-DL-gamma-methylglutaramate, DL-alpha-aminomalonamate, alpha-methyl-DL-asparagine, DL-gamma-methyl-L-glutamine, alpha-methyl-DL-glutamine, DL-beta-methyl-DL-glutamine, DL-proline, DL-alanine and L-tyrosine amide: no substrates | Rattus norvegicus | ? | - |
? | |
3.5.1.3 | additional information | catalyzes hydroxaminolysis and transamidation reactions with esters and amides | Rattus norvegicus | ? | - |
? | |
3.5.1.3 | additional information | catalyzes hydrolysis and hydroxaminolysis | Rattus norvegicus | ? | - |
? | |
3.5.1.3 | succinamate + H2O | amidase activity, hydrolysis proceeds at a slower rate than formation of succinyl hydroxamate in the presence of hydroxylamine | Rattus norvegicus | succinic acid + NH3 | - |
? | |
3.5.1.3 | succinamate + hydroxylamine | catalyzes formation of hydroxamate much more rapidly than hydrolysis of the amide | Rattus norvegicus | succinyl hydroxamate + NH3 | - |
r | |
3.5.1.3 | succinate + hydroxylamine | at pH 5, not at pH 7 | Rattus norvegicus | succinyl hydroxamate + H2O | - |
r | |
3.5.1.3 | succinyl hydroxamate + H2O | - |
Rattus norvegicus | succinate + hydroxylamine | - |
r | |
3.5.1.3 | succinylmonohydroxamate + H2O | - |
Rattus norvegicus | succinate + hydroxylamine | - |
r | |
3.5.1.3 | valeramide + H2O | poor substrate | Rattus norvegicus | valeric acid + NH3 | - |
? |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.5.1.3 | additional information | - |
- |
Rattus norvegicus |
3.5.1.3 | 5 | - |
hydroxamate formation, substrate glutarate or succinate | Rattus norvegicus |
3.5.1.3 | 6.5 | 7.5 | broad pH-optimum, substrate glutaramate or succinamate | Rattus norvegicus |
3.5.1.3 | 6.5 | 7.5 | hydroxaminolysis | Rattus norvegicus |
3.5.1.3 | 7 | - |
hydrolysis and transfer reactions | Rattus norvegicus |
3.5.1.3 | 7 | - |
substrate: succinamate or glutaramate, assay at | Rattus norvegicus |
3.5.1.3 | 8.5 | 9 | pH-optimum for hydroxaminolysis of alpha-ketoglutaramate | Rattus norvegicus |
3.5.1.3 | 9 | - |
optimal for hydrolysis of alpha-ketoglutaramate or alpha-ketosuccinamate | Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
3.5.1.3 | additional information | no requirement for any cofactors for hydroxamate formation | Rattus norvegicus |