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Literature summary extracted from

  • Jellum, E.
    Metabolism of the ketoaldehyde 2-keto-3-deoxyglucose (1968), Biochim. Biophys. Acta, 165, 357-363.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.23 0.03
-
 NAD+
-
 Ovis aries
1.2.1.23 1.2
-
 2-dehydro-3-deoxy-D-glucos
-
 Ovis aries
1.2.1.49 0.4
-
 NADP+
-
 Ovis aries
1.2.1.49 1.2
-
 2-keto-3-deoxy-D-glucose
-
 Ovis aries

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.23 2-dehydro-3-deoxy-D-glucose + NAD+ + H2O Rattus norvegicus
-
 2-dehydro-3-deoxy-D-gluconate + NADH + H+
-
 ?
1.2.1.23 2-dehydro-3-deoxy-D-glucose + NAD+ + H2O Ovis aries
-
 2-dehydro-3-deoxy-D-gluconate + NADH + H+
-
 ?
1.2.1.23 methylglyoxal + NAD+ + H2O Rattus norvegicus i.e. pyruvaldehyde pyruvate + NADH + H+
-
 ?
1.2.1.23 methylglyoxal + NAD+ + H2O Ovis aries i.e. pyruvaldehyde pyruvate + NADH + H+
-
 ?
1.2.1.49 2-keto-3-deoxy-D-glucose + NADP+ + H2O Rattus norvegicus
-
 2-keto-3-deoxy-D-gluconic acid + NADPH + H+
-
 ?
1.2.1.49 2-keto-3-deoxy-D-glucose + NADP+ + H2O Ovis aries
-
 2-keto-3-deoxy-D-gluconic acid + NADPH + H+
-
 ?
1.2.1.49 methylglyoxal + NADP+ + H2O Rattus norvegicus
-
 pyruvate + NADPH + H+
-
 ?
1.2.1.49 methylglyoxal + NADP+ + H2O Ovis aries
-
 pyruvate + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.23 Ovis aries
-
-
-
1.2.1.23 Rattus norvegicus
-
-
-
1.2.1.49 Ovis aries
-
-
-
1.2.1.49 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.23 using treatment with acetone, ammonium sulfate fractionation, and gel filtration on Sephadex G-25 Ovis aries
1.2.1.49 using treatment with acetone, ammonium sulfate fractionation, and gel filtration on Sephadex G-25 Ovis aries

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.23 liver
-
 Rattus norvegicus
-
1.2.1.23 liver
-
 Ovis aries
-
1.2.1.49 liver
-
 Rattus norvegicus
-
1.2.1.49 liver
-
 Ovis aries
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.23 2-dehydro-3-deoxy-D-glucose + NAD+ + H2O
-
 Rattus norvegicus 2-dehydro-3-deoxy-D-gluconate + NADH + H+
-
 ?
1.2.1.23 2-dehydro-3-deoxy-D-glucose + NAD+ + H2O
-
 Ovis aries 2-dehydro-3-deoxy-D-gluconate + NADH + H+
-
 ?
1.2.1.23 2-oxoaldehydes + NAD+ + H2O enzyme from sheep or rat liver also active with NADP+, see also EC 1.2.1.49 Rattus norvegicus 2-oxo acids + NADH
-
 ?
1.2.1.23 2-oxoaldehydes + NAD+ + H2O enzyme from sheep or rat liver also active with NADP+, see also EC 1.2.1.49 Ovis aries 2-oxo acids + NADH
-
 ?
1.2.1.23 methylglyoxal + NAD+ + H2O i.e. pyruvaldehyde Rattus norvegicus pyruvate + NADH + H+
-
 ?
1.2.1.23 methylglyoxal + NAD+ + H2O i.e. pyruvaldehyde Ovis aries pyruvate + NADH + H+
-
 ?
1.2.1.49 2-keto-3-deoxy-D-glucose + NADP+ + H2O
-
 Rattus norvegicus 2-keto-3-deoxy-D-gluconic acid + NADPH + H+
-
 ?
1.2.1.49 2-keto-3-deoxy-D-glucose + NADP+ + H2O
-
 Ovis aries 2-keto-3-deoxy-D-gluconic acid + NADPH + H+
-
 ?
1.2.1.49 2-keto-3-deoxy-D-glucose + NADP+ + H2O
-
 Ovis aries 2-keto-3-deoxy-D-gluconate + NADPH + H+
-
 r
1.2.1.49 2-oxoaldehydes + NADP+ + H2O enzyme from sheep or rat liver also active with NAD+, see also EC 1.2.1.23 Rattus norvegicus 2-oxo acids + NADPH
-
 ?
1.2.1.49 2-oxoaldehydes + NADP+ + H2O enzyme from sheep or rat liver also active with NAD+, see also EC 1.2.1.23 Ovis aries 2-oxo acids + NADPH
-
 ?
1.2.1.49 methylglyoxal + NADP+ + H2O
-
 Rattus norvegicus pyruvate + NADPH + H+
-
 ?
1.2.1.49 methylglyoxal + NADP+ + H2O
-
 Ovis aries pyruvate + NADPH + H+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.23 NAD+
-
 Rattus norvegicus
1.2.1.23 NAD+
-
 Ovis aries
1.2.1.23 NADP+ enzyme from sheep or rat liver, see also EC 1.2.1.49 Rattus norvegicus
1.2.1.23 NADP+ enzyme from sheep or rat liver, see also EC 1.2.1.49 Ovis aries
1.2.1.49 NAD+ enzyme from sheep or rat liver, see also EC 1.2.1.23 Rattus norvegicus
1.2.1.49 NAD+ enzyme from sheep or rat liver, see also EC 1.2.1.23 Ovis aries
1.2.1.49 NADP+
-
 Rattus norvegicus
1.2.1.49 NADP+
-
 Ovis aries