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Literature summary extracted from

  • Tsai, C.S.; Chen, Q.
    Purification and kinetic characterization of 6-phosphogluconate dehydrogenase from Schizosaccharomyces pombe (1998), Biochem. Cell Biol., 76, 637-644.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.44 cloning of the LT2 gnd gene Salmonella enterica subsp. enterica serovar Typhimurium

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.1.1.44
-
 Ovis aries

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.44 D-ribulose 5-phosphate
-
 Cyberlindnera jadinii
1.1.1.44 D-ribulose 5-phosphate
-
 Schizosaccharomyces pombe
1.1.1.44 NADPH
-
 Dicentrarchus labrax
1.1.1.44 NADPH
-
 Neurospora crassa
1.1.1.44 NADPH competitive inhibition Schizosaccharomyces pombe

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.44 Co2+ activated by divalent metal ions Schizosaccharomyces pombe
1.1.1.44 Mn2+ activated by divalent metal ions Schizosaccharomyces pombe

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.44 38000
-
 4 * 38000, SDS-PAGE Schizosaccharomyces pombe
1.1.1.44 158000
-
 gel filtration Schizosaccharomyces pombe

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+ Salmonella enterica subsp. enterica serovar Typhimurium
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Cyberlindnera jadinii
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Pseudomonas sp.
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Leuconostoc mesenteroides
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Gluconobacter oxydans
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Neurospora crassa enzyme specific for the oxidative pentose phosphate pathway D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Ovis aries enzyme specific for the oxidative pentose phosphate pathway D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Dicentrarchus labrax enzyme specific for the oxidative pentose phosphate pathway D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ Schizosaccharomyces pombe pivotal enzyme links the gluconate route and the oxidative phase of the pentose phosphate pathway D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.44 Cyberlindnera jadinii
-
-
-
1.1.1.44 Dicentrarchus labrax
-
 bass
-
1.1.1.44 Gluconobacter oxydans
-
-
-
1.1.1.44 Leuconostoc mesenteroides
-
-
-
1.1.1.44 Neurospora crassa
-
-
-
1.1.1.44 Ovis aries
-
 lamb
-
1.1.1.44 Ovis aries
-
 sheep
-
1.1.1.44 Pseudomonas sp.
-
 P. fluorescens
-
1.1.1.44 Salmonella enterica subsp. enterica serovar Typhimurium
-
 LT2
-
1.1.1.44 Schizosaccharomyces pombe
-
 fission yeast, NCYC 132S2-2
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.44
-
 Schizosaccharomyces pombe

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.44 liver
-
 Ovis aries
-
1.1.1.44 liver
-
 Dicentrarchus labrax
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.44 39.4
-
-
 Schizosaccharomyces pombe

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Salmonella enterica subsp. enterica serovar Typhimurium D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Cyberlindnera jadinii D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Neurospora crassa D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Ovis aries D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Pseudomonas sp. D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Schizosaccharomyces pombe D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Leuconostoc mesenteroides D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Gluconobacter oxydans D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Dicentrarchus labrax D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ enzyme specific for the oxidative pentose phosphate pathway Neurospora crassa D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ enzyme specific for the oxidative pentose phosphate pathway Ovis aries D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ enzyme specific for the oxidative pentose phosphate pathway Dicentrarchus labrax D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ pivotal enzyme links the gluconate route and the oxidative phase of the pentose phosphate pathway Schizosaccharomyces pombe D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r

Subunits

EC Number Subunits Comment Organism
1.1.1.44 tetramer 4 * 38000, SDS-PAGE Schizosaccharomyces pombe

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.44 7.5
-
-
 Cyberlindnera jadinii
1.1.1.44 7.5
-
-
 Schizosaccharomyces pombe

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.44 NADP+
-
 Cyberlindnera jadinii
1.1.1.44 NADP+
-
 Neurospora crassa
1.1.1.44 NADP+
-
 Ovis aries
1.1.1.44 NADP+ requires NADP+ obligatorily for activity Schizosaccharomyces pombe