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Literature summary extracted from

  • Tan, A.W.H.; Smith, C.M.; Aogaichi, T.; Plaut, G.W.E.
    Inhibition of D(-)-3-hydroxybutyrate dehydrogenase by malonate analoges (1975), Arch. Biochem. Biophys., 166, 164-173.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.30 phosphatidylcholine
-
 Cavia porcellus
1.1.1.30 phosphatidylcholine
-
 Rattus norvegicus
1.1.1.30 phosphatidylcholine
-
 Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.30 bromomalonate
-
 Bos taurus
1.1.1.30 bromomalonate
-
 Cavia porcellus
1.1.1.30 bromomalonate
-
 Rattus norvegicus
1.1.1.30 chloromalonate
-
 Bos taurus
1.1.1.30 chloromalonate
-
 Cavia porcellus
1.1.1.30 chloromalonate
-
 Rattus norvegicus
1.1.1.30 dimethylmalonate 15.3 mM, 50% inhibition, oxidation, 11.3% reduction Bos taurus
1.1.1.30 dimethylmalonate 7.6 mM, 50% inhibition, oxidation, 8.5 mM, reduction Cavia porcellus
1.1.1.30 Hydroxymalonate 4.8 mM, 50% inhibition, oxidation, 7.8 reduction Bos taurus
1.1.1.30 Hydroxymalonate 1.8 mM, 50% inhibition, oxidation, 6.0 mM, reduction Cavia porcellus
1.1.1.30 Hydroxymalonate
-
 Rattus norvegicus
1.1.1.30 malonate 9.5 mM, 50% inhibition, oxidation, 8.2 mM Bos taurus
1.1.1.30 malonate 3.7 mM, 50% inhibition, oxidation Cavia porcellus
1.1.1.30 malonate
-
 Rattus norvegicus
1.1.1.30 mesoxalate
-
 Bos taurus
1.1.1.30 mesoxalate
-
 Cavia porcellus
1.1.1.30 mesoxalate
-
 Rattus norvegicus
1.1.1.30 methylmalonate 2.1 mM, 50% inhibition, oxidation Bos taurus
1.1.1.30 methylmalonate 1.4 mM, 50% inhibition, oxidation, 0.8 mM reduction Cavia porcellus
1.1.1.30 methylmalonate
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.30 (R)-3-hydroxybutanoate + NAD+ Cavia porcellus
-
 acetoacetate + NADH
-
 r
1.1.1.30 (R)-3-hydroxybutanoate + NAD+ Rattus norvegicus
-
 acetoacetate + NADH
-
 r
1.1.1.30 (R)-3-hydroxybutanoate + NAD+ Bos taurus
-
 acetoacetate + NADH
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.30 Bos taurus
-
-
-
1.1.1.30 Cavia porcellus
-
-
-
1.1.1.30 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.30 heart
-
 Cavia porcellus
-
1.1.1.30 heart
-
 Rattus norvegicus
-
1.1.1.30 heart
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.30 (R)-3-hydroxybutanoate + NAD+
-
 Cavia porcellus acetoacetate + NADH
-
 r
1.1.1.30 (R)-3-hydroxybutanoate + NAD+
-
 Rattus norvegicus acetoacetate + NADH
-
 r
1.1.1.30 (R)-3-hydroxybutanoate + NAD+
-
 Bos taurus acetoacetate + NADH
-
 r

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.30 NAD+
-
 Cavia porcellus
1.1.1.30 NAD+
-
 Rattus norvegicus
1.1.1.30 NAD+
-
 Bos taurus