BRENDA - Enzyme Database show

The NADP-linked aldehyde reductase from Trypanosoma cruzi subcellular localization and some properties

Arauzo, S.; Cazzulo, J.J.; FEMS Microbiol. Lett. 58, 283-286 (1989)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.2
iodoacetamide
-
Trypanosoma cruzi
1.1.1.2
p-chloromercuribenzoate
-
Trypanosoma cruzi
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.1.1.2
0.004
-
NADPH
n-propanol as substrate
Trypanosoma cruzi
1.1.1.2
0.005
-
NADPH
benzaldehyde as substrate
Trypanosoma cruzi
1.1.1.2
0.014
-
NADPH
propionaldehyde as substrate
Trypanosoma cruzi
1.1.1.2
0.021
-
NADPH
benzyl alcohol as substrate
Trypanosoma cruzi
1.1.1.2
0.22
-
propionaldehyde
-
Trypanosoma cruzi
1.1.1.2
0.58
-
benzaldehyde
-
Trypanosoma cruzi
1.1.1.2
0.8
-
p-nitrobenzaldehyde
-
Trypanosoma cruzi
1.1.1.2
1.43
-
benzyl alcohol
-
Trypanosoma cruzi
1.1.1.2
100
-
n-Propanol
-
Trypanosoma cruzi
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.1.1.2
cytosol
-
Trypanosoma cruzi
5829
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.2
Crithidia fasciculata
-
-
-
1.1.1.2
Neurospora crassa
-
-
-
1.1.1.2
Trypanosoma cruzi
-
Tulahuen strain, Tul 0 stock
-
Purification (Commentary)
EC Number
Commentary
Organism
1.1.1.2
-
Crithidia fasciculata
1.1.1.2
-
Trypanosoma cruzi
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.2
epimastigote
-
Trypanosoma cruzi
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
1.1.1.2
2.25
-
-
Trypanosoma cruzi
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.2
1-pentanol + NADP+
-
286193
Trypanosoma cruzi
n-pentanal + NADPH
-
-
-
r
1.1.1.2
acetaldehyde + NADPH + H+
-
286193
Trypanosoma cruzi
ethanol + NADP+
-
-
-
?
1.1.1.2
anisaldehyde + NADPH + H+
-
286193
Trypanosoma cruzi
anisyl alcohol + NADP+
-
-
-
r
1.1.1.2
benzaldehyde + NADPH
-
286193
Trypanosoma cruzi
benzyl alcohol + NADP+
-
-
-
r
1.1.1.2
benzyl alcohol + NADP+
-
286193
Trypanosoma cruzi
benzaldehyde + NADPH
-
-
-
r
1.1.1.2
ethanol + NADP+
-
286193
Trypanosoma cruzi
acetaldehyde + NADPH + H+
-
-
-
r
1.1.1.2
additional information
acetone is no substrate
286193
Trypanosoma cruzi
?
-
-
-
-
1.1.1.2
n-butanol + NADP+
-
286193
Trypanosoma cruzi
butyraldehyde + NADPH
-
-
-
r
1.1.1.2
n-propanol + NADP+
-
286193
Trypanosoma cruzi
propionaldehyde + NADPH
-
-
-
r
1.1.1.2
p-nitrobenzaldehyde + NADPH
-
286193
Trypanosoma cruzi
p-nitrobenzylalcohol + NADP+
-
-
-
-
1.1.1.2
propionaldehyde + NADPH
-
286193
Trypanosoma cruzi
propanol + NADP+
-
-
-
r
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
1.1.1.2
7
8
propionaldehyde as substrate
Trypanosoma cruzi
1.1.1.2
9
9.5
n-propanol as substrate
Trypanosoma cruzi
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.2
iodoacetamide
-
Trypanosoma cruzi
1.1.1.2
p-chloromercuribenzoate
-
Trypanosoma cruzi
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.1.1.2
0.004
-
NADPH
n-propanol as substrate
Trypanosoma cruzi
1.1.1.2
0.005
-
NADPH
benzaldehyde as substrate
Trypanosoma cruzi
1.1.1.2
0.014
-
NADPH
propionaldehyde as substrate
Trypanosoma cruzi
1.1.1.2
0.021
-
NADPH
benzyl alcohol as substrate
Trypanosoma cruzi
1.1.1.2
0.22
-
propionaldehyde
-
Trypanosoma cruzi
1.1.1.2
0.58
-
benzaldehyde
-
Trypanosoma cruzi
1.1.1.2
0.8
-
p-nitrobenzaldehyde
-
Trypanosoma cruzi
1.1.1.2
1.43
-
benzyl alcohol
-
Trypanosoma cruzi
1.1.1.2
100
-
n-Propanol
-
Trypanosoma cruzi
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.1.1.2
cytosol
-
Trypanosoma cruzi
5829
-
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
1.1.1.2
-
Crithidia fasciculata
1.1.1.2
-
Trypanosoma cruzi
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.2
epimastigote
-
Trypanosoma cruzi
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
1.1.1.2
2.25
-
-
Trypanosoma cruzi
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.2
1-pentanol + NADP+
-
286193
Trypanosoma cruzi
n-pentanal + NADPH
-
-
-
r
1.1.1.2
acetaldehyde + NADPH + H+
-
286193
Trypanosoma cruzi
ethanol + NADP+
-
-
-
?
1.1.1.2
anisaldehyde + NADPH + H+
-
286193
Trypanosoma cruzi
anisyl alcohol + NADP+
-
-
-
r
1.1.1.2
benzaldehyde + NADPH
-
286193
Trypanosoma cruzi
benzyl alcohol + NADP+
-
-
-
r
1.1.1.2
benzyl alcohol + NADP+
-
286193
Trypanosoma cruzi
benzaldehyde + NADPH
-
-
-
r
1.1.1.2
ethanol + NADP+
-
286193
Trypanosoma cruzi
acetaldehyde + NADPH + H+
-
-
-
r
1.1.1.2
additional information
acetone is no substrate
286193
Trypanosoma cruzi
?
-
-
-
-
1.1.1.2
n-butanol + NADP+
-
286193
Trypanosoma cruzi
butyraldehyde + NADPH
-
-
-
r
1.1.1.2
n-propanol + NADP+
-
286193
Trypanosoma cruzi
propionaldehyde + NADPH
-
-
-
r
1.1.1.2
p-nitrobenzaldehyde + NADPH
-
286193
Trypanosoma cruzi
p-nitrobenzylalcohol + NADP+
-
-
-
-
1.1.1.2
propionaldehyde + NADPH
-
286193
Trypanosoma cruzi
propanol + NADP+
-
-
-
r
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
1.1.1.2
7
8
propionaldehyde as substrate
Trypanosoma cruzi
1.1.1.2
9
9.5
n-propanol as substrate
Trypanosoma cruzi