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Literature summary extracted from

  • De Jongh, K.S.; Schofield, P.J.; Edwards, M.R.
    Kinetic mechanism of sheep liver NADPH-dependent aldehyde reductase (1987), Biochem. J., 242, 143-150.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.2 2-ethylhexanoate
-
 Ovis aries
1.1.1.2 Alrestatin liver ALR1 Ovis aries
1.1.1.2 D-glucuronate high concentrations, inhibition in a non-competitive manner Ovis aries
1.1.1.2 Phenobarbitone
-
 Ovis aries
1.1.1.2 pyridine 3-aldehyde
-
 Ovis aries
1.1.1.2 sodium valproate
-
 Bos taurus
1.1.1.2 sodium valproate liver ALR1 Ovis aries
1.1.1.2 sorbinil liver ALR1 Ovis aries
1.1.1.2 sorbinil
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.2 0.001
-
 NADPH p-nitrobenzaldehyde as substrate Ovis aries
1.1.1.2 0.0016
-
 NADPH pyridine 3-aldehyde as substrate Ovis aries
1.1.1.2 0.0019
-
 NADPH D-glucuronate as substrate Ovis aries
1.1.1.2 0.044
-
 p-nitrobenzaldehyde
-
 Ovis aries
1.1.1.2 1.2
-
 p-nitrobenzaldehyde
-
 Ovis aries
1.1.1.2 1.5
-
 D-glucuronate
-
 Ovis aries

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.2 D-glucuronate + NADPH Rattus norvegicus
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH Bos taurus
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH Ovis aries
-
 L-gulonate + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.2 Bos taurus
-
 ox
-
1.1.1.2 Ovis aries
-
 sheep
-
1.1.1.2 Ovis aries
-
 Suffolk-Hampshire
-
1.1.1.2 Rattus norvegicus
-
 rat
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.2 ALR1 Ovis aries

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.2 brain
-
 Rattus norvegicus
-
1.1.1.2 brain
-
 Bos taurus
-
1.1.1.2 brain
-
 Ovis aries
-
1.1.1.2 kidney
-
 Rattus norvegicus
-
1.1.1.2 kidney
-
 Bos taurus
-
1.1.1.2 kidney
-
 Ovis aries
-
1.1.1.2 liver
-
 Rattus norvegicus
-
1.1.1.2 liver
-
 Bos taurus
-
1.1.1.2 liver
-
 Ovis aries
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
 Rattus norvegicus 3-pyridinemethanol + NADP+
-
 r
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
 Bos taurus 3-pyridinemethanol + NADP+
-
 ?
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
 Ovis aries 3-pyridinemethanol + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Rattus norvegicus L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Rattus norvegicus L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Bos taurus L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Bos taurus L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Ovis aries L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Ovis aries L-gulonate + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
 Rattus norvegicus p-nitrobenzylalcohol + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
 Bos taurus p-nitrobenzylalcohol + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
 Ovis aries p-nitrobenzylalcohol + NADP+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.2 daunorubicin reductase
-
 Rattus norvegicus
1.1.1.2 daunorubicin reductase
-
 Ovis aries
1.1.1.2 L-hexonate dehydrogenase
-
 Bos taurus
1.1.1.2 L-hexonate dehydrogenase
-
 Ovis aries