EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.141 | 15-ketoprostaglandin E2 | - |
Sus scrofa | |
1.1.1.141 | adenosine-5'-diphosphoribose | - |
Sus scrofa | |
1.1.1.141 | NAD+ | product inhibition | Sus scrofa | |
1.1.1.141 | NADH | - |
Sus scrofa | |
1.1.1.141 | prostaglandin E2 | product inhibition | Sus scrofa |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.141 | 0.00158 | - |
prostaglandin E2 | - |
Sus scrofa | |
1.1.1.141 | 0.0384 | - |
NAD+ | - |
Sus scrofa |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.141 | Sus scrofa | - |
- |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
1.1.1.141 | (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ = (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | NAD+ is added first, followed by prostaglandin E2, 15-ketoprostaglandin is released followed by NADH | Sus scrofa | |
1.1.1.141 | (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ = (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | ordered bi-bi-mechanism | Sus scrofa |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.141 | kidney | - |
Sus scrofa | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.141 | (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | - |
Sus scrofa | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? | |
1.1.1.141 | 11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+ | - |
Sus scrofa | 11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH | - |
? |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.141 | NAD+ | - |
Sus scrofa |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.141 | 0.0135 | - |
NADH | NAD+ as the variable substrate | Sus scrofa | |
1.1.1.141 | 0.02 | - |
15-ketoprostaglandin E2 | prostaglandin E2 as the variable substrate | Sus scrofa | |
1.1.1.141 | 0.02 | - |
adenosine-5'-diphosphoribose | prostaglandin E2 as the variable substrate | Sus scrofa | |
1.1.1.141 | 0.031 | - |
15-ketoprostaglandin E2 | NAD+ as the variable substrate | Sus scrofa | |
1.1.1.141 | 0.225 | - |
adenosine-5'-diphosphoribose | NAD+ as the variable substrate | Sus scrofa |