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Literature summary extracted from
- Purification and some molecular properties of horse liver acyl phosphatase (1972), Biochim. Biophys. Acta, 284, 485-496.
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 3.6.1.7 | liver enzyme, stable to acid treatment | Equus caballus |
| 3.6.1.7 | two acyl phosphatase activities in liver, one labile and the other acid, heat stable | Equus caballus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.6.1.7 | phosphate | - |
Equus caballus |  |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.6.1.7 | 8300 | - |
liver, gel filtration | Equus caballus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.1.7 | 1,3-diphosphoglycerate + H2O | Equus caballus | carbamoyl phosphate and 1,3-diphosphoglycerate can acylate and carbamylate some proteins, acyl phosphatase could prevent such acylation and carbamylation, exerting a regulatory role on the intracellular concentration of 1,3-diphosphoglycerate and carbamoyl phosphate | 3-phosphoglycerate + phosphate | - |
? | |
| 3.6.1.7 | 1,3-diphosphoglycerate + H2O | Equus caballus | possible physiological substrate | 3-phosphoglycerate + phosphate | - |
? | |
| 3.6.1.7 | carbamoyl phosphate + H2O | Equus caballus | carbamoyl phosphate and 1,3-diphosphoglycerate can acylate and carbamylate some proteins, acyl phosphatase could prevent such acylation and carbamylation, exerting a regulatory role on the intracellular concentration of 1,3-diphosphoglycerate and carbamoyl phosphate | carbamate + phosphate | - |
? | |
| 3.6.1.7 | carbamoyl phosphate + H2O | Equus caballus | liver enzyme, carbamoyl phosphate can reach high concentrations in liver and its level may be partly controlled by acyl phosphatase | carbamate + phosphate | - |
? | |
| 3.6.1.7 | carbamoyl phosphate + H2O | Equus caballus | possible physiological substrate | carbamate + phosphate | - |
? | |
| 3.6.1.7 | additional information | Equus caballus | carbamoyl phosphate and 1,3-diphosphoglycerate can acylate and carbamylate some proteins, acyl phosphatase could prevent such acylation and carbamylation, exerting a regulatory role on the intracellular concentration of 1,3-diphosphoglycerate and carbamoyl phosphate | ? | - |
? | |
| 3.6.1.7 | additional information | Equus caballus | possible role in regulating the glycolytic pathway, ureogenesis and pyrimidine biosynthesis | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.6.1.7 | Equus caballus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.6.1.7 | liver | Equus caballus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.6.1.7 | brain | - |
Equus caballus | - |
| 3.6.1.7 | liver | - |
Equus caballus | - |
| 3.6.1.7 | muscle | - |
Equus caballus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.6.1.7 | 2800 | - |
liver | Equus caballus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.1.7 | 1,3-diphosphoglycerate + H2O | - |
Equus caballus | 3-phosphoglycerate + phosphate | - |
? | |
| 3.6.1.7 | 1,3-diphosphoglycerate + H2O | carbamoyl phosphate and 1,3-diphosphoglycerate can acylate and carbamylate some proteins, acyl phosphatase could prevent such acylation and carbamylation, exerting a regulatory role on the intracellular concentration of 1,3-diphosphoglycerate and carbamoyl phosphate | Equus caballus | 3-phosphoglycerate + phosphate | - |
? | |
| 3.6.1.7 | 1,3-diphosphoglycerate + H2O | possible physiological substrate | Equus caballus | 3-phosphoglycerate + phosphate | - |
? | |
| 3.6.1.7 | acetyl phosphate + H2O | - |
Equus caballus | acetate + phosphate | - |
? | |
| 3.6.1.7 | acylphosphate + H2O | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Equus caballus | carboxylate + phosphate | - |
? | |
| 3.6.1.7 | ATP + H2O | liver enzyme, no activity | Equus caballus | ? | - |
? | |
| 3.6.1.7 | benzoyl phosphate + H2O | - |
Equus caballus | benzoate + phosphate | - |
? | |
| 3.6.1.7 | carbamoyl phosphate + H2O | - |
Equus caballus | carbamate + phosphate | - |
? | |
| 3.6.1.7 | carbamoyl phosphate + H2O | carbamoyl phosphate and 1,3-diphosphoglycerate can acylate and carbamylate some proteins, acyl phosphatase could prevent such acylation and carbamylation, exerting a regulatory role on the intracellular concentration of 1,3-diphosphoglycerate and carbamoyl phosphate | Equus caballus | carbamate + phosphate | - |
? | |
| 3.6.1.7 | carbamoyl phosphate + H2O | liver enzyme, carbamoyl phosphate can reach high concentrations in liver and its level may be partly controlled by acyl phosphatase | Equus caballus | carbamate + phosphate | - |
? | |
| 3.6.1.7 | carbamoyl phosphate + H2O | possible physiological substrate | Equus caballus | carbamate + phosphate | - |
? | |
| 3.6.1.7 | diphosphate + H2O | liver enzyme, no activity | Equus caballus | 2 phosphate | - |
? | |
| 3.6.1.7 | additional information | substrate specificity | Equus caballus | ? | - |
? | |
| 3.6.1.7 | additional information | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Equus caballus | ? | - |
? | |
| 3.6.1.7 | additional information | acetyl-AMP: not a substrate | Equus caballus | ? | - |
? | |
| 3.6.1.7 | additional information | liver enzyme and muscle enzyme, no activity with acetyl-AMP, phosphoenolpyruvate and phosvitin | Equus caballus | ? | - |
? | |
| 3.6.1.7 | additional information | relative hydrolysis rates | Equus caballus | ? | - |
? | |
| 3.6.1.7 | additional information | carbamoyl phosphate and 1,3-diphosphoglycerate can acylate and carbamylate some proteins, acyl phosphatase could prevent such acylation and carbamylation, exerting a regulatory role on the intracellular concentration of 1,3-diphosphoglycerate and carbamoyl phosphate | Equus caballus | ? | - |
? | |
| 3.6.1.7 | additional information | possible role in regulating the glycolytic pathway, ureogenesis and pyrimidine biosynthesis | Equus caballus | ? | - |
? | |
| 3.6.1.7 | p-nitrobenzoyl phosphate + H2O | - |
Equus caballus | p-nitrobenzoate + phosphate | - |
? | |
| 3.6.1.7 | p-nitrophenyl phosphate + H2O | liver enzyme, no activity at pH 5.3 and 10.4 | Equus caballus | p-nitrophenol + phosphate | - |
? | |
| 3.6.1.7 | phosphocreatine + H2O | liver enzyme, no activity | Equus caballus | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.6.1.7 | monomer | liver, 1 * 8300, SDS-PAGE | Equus caballus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.6.1.7 | 25 | - |
assay at | Equus caballus |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.6.1.7 | additional information | - |
enzyme is thermostable | Equus caballus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.6.1.7 | 5.3 | - |
assay at | Equus caballus |
pH Stability
| EC Number | pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.6.1.7 | additional information | - |
liver enzyme is acid stable | Equus caballus |
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