Literature summary extracted from

Baker, A.S.; Ciocci, M.J.; Metcalf, W.W.; Kim, J.; Babbitt, P.C.; Wanner, B.L.; Martin, B.M.; Dunaway-Mariano, D.
Insight into the mechanism of catalysis by the P-C cleaving enzyme phosphonoacetaldehyde hydrolase derived from gene sequence analysis and mutagenesis (1998), Biochemistry, 37, 9305-9315.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.11.1.1	high-level-expression in E coli	Salmonella enterica subsp. enterica serovar Typhimurium

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.11.1.1	Bacillus cereus	-	-	-
3.11.1.1	Salmonella enterica subsp. enterica serovar Typhimurium	-	-	-

Reaction

EC Number	Reaction	Comment	Organism	Reaction ID
3.11.1.1	phosphonoacetaldehyde + H2O = acetaldehyde + phosphate	mechanism involves Schiff base formation with Lys53 followed by phosphoryl transfer to Asp11 and at last hydrolysis at the imine and acyl phosphate phosphorus	Salmonella enterica subsp. enterica serovar Typhimurium	a
3.11.1.1	phosphonoacetaldehyde + H2O = acetaldehyde + phosphate	mechanism involves Schiff base formation with Lys53 followed by phosphoryl transfer to Asp12 and at last hydrolysis at the imine and acyl phosphate phosphorus	Bacillus cereus	a

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.11.1.1	phosphonoacetylaldehyde + H2O	-	Salmonella enterica subsp. enterica serovar Typhimurium	acetaldehyde + phosphate	-	?
3.11.1.1	phosphonoacetylaldehyde + H2O	-	Bacillus cereus	acetaldehyde + phosphate	-	?

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Release 2023.1 (January 2023)