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Literature summary extracted from

  • Ito, N.; Tomizawa, K.; Tanaka, K.; Matsui, M.; Kendrick, R.E.; Sato, T.; Nakagawa, H.
    Characterization of 26S proteasome alpha- and beta-type and ATPase subunits from spinach and their expression during early stages of seedling development (1997), Plant Mol. Biol., 34, 307-316.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.6.1.5 cDNAs encoding 26Sproteasome subunits, genes SOPSC8, SOPSC1 and SOPRS7 from the 19/22S regulatory complex Spinacia oleracea
5.6.1.5 human ATPase subunit MSS1 gene used for screening Homo sapiens
5.6.1.5 several subunit genes of the 20S catalytic core and the 19/22S regulatory complex have been isolated Solanum lycopersicum
5.6.1.5 several subunit genes of the 20S catalytic core and the 19/22S regulatory complex have been isolated Oryza sativa
5.6.1.5 several subunit genes of the 20S catalytic core and the 19/22S regulatory complex have been isolated, MBP1 gene of the 19/22S regulatory complex cloned Arabidopsis sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.6.1.5 ATP + H2O + polypeptide Homo sapiens
-
 ADP + phosphate + unfolded polypeptide
-
 ?
5.6.1.5 ATP + H2O + polypeptide Rattus norvegicus
-
 ADP + phosphate + unfolded polypeptide
-
 ?
5.6.1.5 ATP + H2O + polypeptide Saccharomyces cerevisiae
-
 ADP + phosphate + unfolded polypeptide
-
 ?
5.6.1.5 ATP + H2O + polypeptide Spinacia oleracea
-
 ADP + phosphate + unfolded polypeptide
-
 ?
5.6.1.5 ATP + H2O + polypeptide Xenopus laevis
-
 ADP + phosphate + unfolded polypeptide
-
 ?
5.6.1.5 ATP + H2O + polypeptide Arabidopsis sp.
-
 ADP + phosphate + unfolded polypeptide
-
 ?
5.6.1.5 ATP + H2O + polypeptide Solanum lycopersicum
-
 ADP + phosphate + unfolded polypeptide
-
 ?
5.6.1.5 ATP + H2O + polypeptide Oryza sativa
-
 ADP + phosphate + unfolded polypeptide
-
 ?
5.6.1.5 ATP + H2O + polypeptide Thermoplasma sp.
-
 ADP + phosphate + unfolded polypeptide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.25.1 Spinacia oleracea
-
 spinach
-
5.6.1.5 Arabidopsis sp.
-
-
-
5.6.1.5 Homo sapiens
-
-
-
5.6.1.5 Oryza sativa
-
 rice
-
5.6.1.5 Rattus norvegicus
-
 rat
-
5.6.1.5 Saccharomyces cerevisiae
-
-
-
5.6.1.5 Solanum lycopersicum
-
-
-
5.6.1.5 Spinacia oleracea
-
-
-
5.6.1.5 Thermoplasma sp.
-
 acidophilum
-
5.6.1.5 Xenopus laevis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.6.1.5 26Sproteasome Spinacia oleracea

Reaction

EC Number Reaction Comment Organism Reaction ID
5.6.1.5 ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome Homo sapiens
a
5.6.1.5 ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome Rattus norvegicus
a
5.6.1.5 ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome Saccharomyces cerevisiae
a
5.6.1.5 ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome Spinacia oleracea
a
5.6.1.5 ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome Xenopus laevis
a
5.6.1.5 ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome Arabidopsis sp.
a
5.6.1.5 ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome Solanum lycopersicum
a
5.6.1.5 ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome Oryza sativa
a
5.6.1.5 ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome Thermoplasma sp.
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.25.1 perisperm after germination, northern blot analysis Spinacia oleracea
-
3.4.25.1 seed
-
 Spinacia oleracea
-
5.6.1.5 cotyledon
-
 Spinacia oleracea
-
5.6.1.5 hypocotyl
-
 Spinacia oleracea
-
5.6.1.5 root
-
 Spinacia oleracea
-
5.6.1.5 seed
-
 Spinacia oleracea
-
5.6.1.5 seedling
-
 Spinacia oleracea
-
5.6.1.5 shoot
-
 Spinacia oleracea
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.1.5 ATP + H2O + polypeptide
-
 Homo sapiens ADP + phosphate + unfolded polypeptide
-
 ?
5.6.1.5 ATP + H2O + polypeptide
-
 Rattus norvegicus ADP + phosphate + unfolded polypeptide
-
 ?
5.6.1.5 ATP + H2O + polypeptide
-
 Saccharomyces cerevisiae ADP + phosphate + unfolded polypeptide
-
 ?
5.6.1.5 ATP + H2O + polypeptide
-
 Spinacia oleracea ADP + phosphate + unfolded polypeptide
-
 ?
5.6.1.5 ATP + H2O + polypeptide
-
 Xenopus laevis ADP + phosphate + unfolded polypeptide
-
 ?
5.6.1.5 ATP + H2O + polypeptide
-
 Arabidopsis sp. ADP + phosphate + unfolded polypeptide
-
 ?
5.6.1.5 ATP + H2O + polypeptide
-
 Solanum lycopersicum ADP + phosphate + unfolded polypeptide
-
 ?
5.6.1.5 ATP + H2O + polypeptide
-
 Oryza sativa ADP + phosphate + unfolded polypeptide
-
 ?
5.6.1.5 ATP + H2O + polypeptide
-
 Thermoplasma sp. ADP + phosphate + unfolded polypeptide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.6.1.5 26S proteasome
-
 Homo sapiens
5.6.1.5 26S proteasome
-
 Rattus norvegicus
5.6.1.5 26S proteasome
-
 Saccharomyces cerevisiae
5.6.1.5 26S proteasome
-
 Spinacia oleracea
5.6.1.5 26S proteasome
-
 Xenopus laevis
5.6.1.5 26S proteasome
-
 Thermoplasma sp.