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Literature summary extracted from
- Phosphoribosyladenosine monophosphate, an intermediate in histidine biosynthesis (1965), J. Biol. Chem., 240, 3056-3063.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.6.1.31 | EDTA | - |
Salmonella enterica subsp. enterica serovar Typhimurium |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.6.1.31 | 0.022 | - |
N-1-(5'-phosphoribosyl)-ATP | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.6.1.31 | Mg2+ | required, optimum concentration 0.03 M | Salmonella enterica subsp. enterica serovar Typhimurium | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.6.1.31 | 43000 | - |
sucrose density gradient centrifugation | Salmonella enterica subsp. enterica serovar Typhimurium |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.1.31 | N-1-(5'-phosphoribosyl)-ATP + H2O | Salmonella enterica subsp. enterica serovar Typhimurium | enzyme of histidine biosynthesis pathway | N-1-(5'-phosphoribosyl)-AMP + diphosphate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.6.1.31 | Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.6.1.31 | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.6.1.31 | 0.003 | - |
- |
Salmonella enterica subsp. enterica serovar Typhimurium |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.1.31 | N-1-(5'-phosphoribosyl)-ATP + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium | N-1-(5'-phosphoribosyl)-AMP + diphosphate | - |
ir | |
| 3.6.1.31 | N-1-(5'-phosphoribosyl)-ATP + H2O | enzyme of histidine biosynthesis pathway | Salmonella enterica subsp. enterica serovar Typhimurium | N-1-(5'-phosphoribosyl)-AMP + diphosphate | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.6.1.31 | 9 | - |
- |
Salmonella enterica subsp. enterica serovar Typhimurium |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.6.1.31 | 7 | 10 | 75% of maximum activity at pH 7, 79% of maximum activity at pH 10 | Salmonella enterica subsp. enterica serovar Typhimurium |
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Release 2023.1 (January 2023)
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