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Literature summary extracted from
- Stereospecific synthesis and enzyme studies of CDP-diacylglycerols (1982), Biochim. Biophys. Acta, 712, 473-483.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.6.1.26 | Triton X-100 | detergent required for activity, optimum concentration 0.3% | Cavia porcellus |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.7.8.11 | AMP | non-competitive inhibition | Cavia porcellus | |
| 3.6.1.26 | AMP | none competitive, Ki: 0.04 mM | Cavia porcellus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 2.7.8.11 | 0.03 | - |
CDP-1-stearoyl-2-oleoylglycerol | pH 8.3, 37°C | Cavia porcellus | |
| 2.7.8.11 | 0.045 | - |
CDP-1-stearoyl-2-arachidonoylglycerol | pH 8.3, 37°C | Cavia porcellus | |
| 2.7.8.11 | 0.05 | - |
CDP-dipalmitoyl-sn-glycerol | pH 8.3, 37°C | Cavia porcellus | |
| 2.7.8.11 | 0.16 | - |
CDP-distearoylglycerol | pH 8.3, 37°C | Cavia porcellus | |
| 3.6.1.26 | 0.04 | - |
CDP-1-stearoyl-2-oleoylglycerol | - |
Cavia porcellus | |
| 3.6.1.26 | 0.047 | - |
CDP-1-stearoyl-2-stearoylglycerol | - |
Cavia porcellus | |
| 3.6.1.26 | 0.063 | - |
CDPdipalmitoylglycerol | - |
Cavia porcellus | |
| 3.6.1.26 | 0.14 | - |
CDPdistearoylglycerol | - |
Cavia porcellus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.6.1.26 | lysosome | - |
Cavia porcellus | 5764 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.7.8.11 | CDP-diacylglycerol + myo-inositol | Cavia porcellus | - |
CMP + phosphatidyl-1D-myo-inositol | - |
r | |
| 3.6.1.26 | CDPdiacylglycerol + H2O | Cavia porcellus | - |
CMP + phosphatidate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.7.8.11 | Cavia porcellus | - |
guinea pig | - |
| 3.6.1.26 | Cavia porcellus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.6.1.26 | - |
Cavia porcellus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 2.7.8.11 | brain | - |
Cavia porcellus | - |
| 3.6.1.26 | brain | - |
Cavia porcellus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.7.8.11 | CDP-1-arachidonoyl-2-stearoylglycerol + myo-inositol | 6% of the activity with CDP-1-stearoyl-2-oleoylglycerol | Cavia porcellus | CMP + 1-arachidonoyl-2-stearoylphosphtidylinositol | - |
r | |
| 2.7.8.11 | CDP-1-stearoyl-2-arachidonoylglycerol + myo-inositol | 4% of the activity with CDP-1-stearoyl-2-oleoylglycerol | Cavia porcellus | CMP + 1-stearoyl-2-arachidonoylphosphatidylinositol | - |
r | |
| 2.7.8.11 | CDP-1-stearoyl-2-oleoylglycerol + myo-inositol | - |
Cavia porcellus | CMP + 1-stearoyl-2-oleoylphosphatidylinositol | - |
r | |
| 2.7.8.11 | CDP-diacylglycerol + myo-inositol | - |
Cavia porcellus | CMP + phosphatidyl-1D-myo-inositol | - |
r | |
| 2.7.8.11 | CDP-diarachidonoylglycerol + myo-inositol | 9% of the activity with CDP-1-stearoyl-2-oleoylglycerol | Cavia porcellus | CMP + diarachidonoylphosphatidylinositol | - |
r | |
| 2.7.8.11 | CDP-dipalmitoyl-sn-glycerol + myo-inositol | - |
Cavia porcellus | CMP + dipalmitoylphosphatidylinositol | - |
? | |
| 2.7.8.11 | CDP-distearoylglycerol + myo-inositol | 38% of the activity with CDP-1-stearoyl-2-oleoylglycerol | Cavia porcellus | CMP + distearoylphosphatidylinositol | - |
r | |
| 2.7.8.11 | CDPdipalmitoyl-sn-glycerol + myo-inositol | 70% of the activity with CDP-1-stearoyl-2-oleoylglycerol | Cavia porcellus | CMP + dipalmitoylphosphatidylinositol | - |
r | |
| 3.6.1.26 | CDP-1-stearoyl-2-oleoylglycerol + H2O | - |
Cavia porcellus | CMP + 1-stearoyl-2-oleoyl-sn-glycerol-3-phosphate | - |
? | |
| 3.6.1.26 | CDP-1-stearoyl-2-stearoylglycerol + H2O | - |
Cavia porcellus | CMP + 1,2-distearoyl-sn-glycerol-3-phosphate | - |
? | |
| 3.6.1.26 | CDPdiacylglycerol + H2O | - |
Cavia porcellus | CMP + phosphatidate | - |
? | |
| 3.6.1.26 | CDPdipalmitoylglycerol + H2O | - |
Cavia porcellus | CMP + 1,2-dipalmitoyl-sn-glycerol-3-phosphate | - |
? | |
| 3.6.1.26 | CDPdistearoylglycerol + H2O | - |
Cavia porcellus | CMP + 1,2-distearoyl-sn-glycerol-3-phosphate | - |
? | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 2.7.8.11 | 0.04 | - |
AMP | pH 8.3, 37°C | Cavia porcellus | |
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