EC Number | Cloned (Comment) | Organism |
---|---|---|
3.5.2.6 | expressed in Escherichia coli | Bacillus cereus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.5.2.6 | D104A | km for benzylpenicillin and methicillin increased 2 fold, no change in catalytic activity | Bacillus cereus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.5.2.6 | 6-beta-trifluoromethanesulfonamidopenicillanic acid | - |
Bacillus cereus | |
3.5.2.6 | 6-bromopenicillanic acid | - |
Bacillus cereus | |
3.5.2.6 | clavulanic acid | - |
Staphylococcus aureus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.5.2.6 | extracellular | - |
Staphylococcus aureus | - |
- |
3.5.2.6 | extracellular | - |
Bacillus cereus | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.2.6 | ampicillin + H2O | Bacillus cereus | - |
(2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
3.5.2.6 | ampicillin + H2O | Bacillus cereus 569/H/9 | - |
(2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.2.6 | Bacillus cereus | - |
- |
- |
3.5.2.6 | Bacillus cereus 569/H/9 | - |
- |
- |
3.5.2.6 | Staphylococcus aureus | - |
- |
- |
3.5.2.6 | Staphylococcus aureus PC1 | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.5.2.6 | - |
Staphylococcus aureus |
3.5.2.6 | - |
Bacillus cereus |
EC Number | Storage Stability | Organism |
---|---|---|
3.5.2.6 | -20°C, 50 mM sodium phosphate buffer, pH 6.8, 50% glycerol | Staphylococcus aureus |
3.5.2.6 | -20°C, 50 mM sodium phosphate buffer, pH 6.8, 50% glycerol | Bacillus cereus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.2.6 | ampicillin + H2O | - |
Staphylococcus aureus | (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
3.5.2.6 | ampicillin + H2O | - |
Bacillus cereus | (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
3.5.2.6 | ampicillin + H2O | - |
Bacillus cereus 569/H/9 | (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
3.5.2.6 | ampicillin + H2O | - |
Staphylococcus aureus PC1 | (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
3.5.2.6 | benzylpenicillin + H2O | - |
Staphylococcus aureus | (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
3.5.2.6 | benzylpenicillin + H2O | - |
Bacillus cereus | (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
3.5.2.6 | benzylpenicillin + H2O | - |
Bacillus cereus 569/H/9 | (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
3.5.2.6 | benzylpenicillin + H2O | - |
Staphylococcus aureus PC1 | (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
3.5.2.6 | methicillin + H2O | - |
Bacillus cereus | (2R,4S)-2-[(R)-carboxy(2,6-dimethoxybenzamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
3.5.2.6 | methicillin + H2O | - |
Bacillus cereus 569/H/9 | (2R,4S)-2-[(R)-carboxy(2,6-dimethoxybenzamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
3.5.2.6 | oxacillin + H2O | - |
Staphylococcus aureus | (2R,4S)-2-{(R)-carboxy[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
3.5.2.6 | oxacillin + H2O | - |
Bacillus cereus | (2R,4S)-2-{(R)-carboxy[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
3.5.2.6 | oxacillin + H2O | - |
Bacillus cereus 569/H/9 | (2R,4S)-2-{(R)-carboxy[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
3.5.2.6 | oxacillin + H2O | - |
Staphylococcus aureus PC1 | (2R,4S)-2-{(R)-carboxy[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.5.2.6 | beta-lactamse A-D | A,C and D enzymes utilize a nucleophilic serine at the active center which becomes acylated by substrate, B enzymes are metalloenzymes requiring Zn2+ for activity | Staphylococcus aureus |
3.5.2.6 | beta-lactamse A-D | A,C and D enzymes utilize a nucleophilic serine at the active center which becomes acylated by substrate, B enzymes are metalloenzymes requiring Zn2+ for activity | Bacillus cereus |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.5.2.6 | 8 | - |
Oxacillin | - |
Staphylococcus aureus | |
3.5.2.6 | 135 | - |
benzylpenicillin | - |
Staphylococcus aureus | |
3.5.2.6 | 145 | - |
Methicillin | - |
Bacillus cereus | |
3.5.2.6 | 261 | - |
Oxacillin | - |
Bacillus cereus | |
3.5.2.6 | 550 | - |
ampicillin | - |
Staphylococcus aureus | |
3.5.2.6 | 1350 | - |
benzylpenicillin | - |
Bacillus cereus | |
3.5.2.6 | 5400 | - |
ampicillin | - |
Bacillus cereus |