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Literature summary extracted from

  • Jahnke, K.; Podschun, B.; Schnackerz, K.D.; Kautz, J.; Cook, P.F.
    Acid-base catalytic mechanism of dihydropyrimidinase from pH studies (1993), Biochemistry, 32, 5160-5166.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.2.2 2,6-dipicolinic acid
-
 Bos taurus
3.5.2.2 2,6-dipicolinic acid
-
 Sus scrofa
3.5.2.2 4-ureidobutyric acid
-
 Sus scrofa
3.5.2.2 5-amino-n-valeric acid
-
 Sus scrofa
3.5.2.2 8-Hydroxyquinoline-5-sulfonic acid
-
 Bos taurus
3.5.2.2 8-Hydroxyquinoline-5-sulfonic acid
-
 Sus scrofa
3.5.2.2 beta-Alanine
-
 Sus scrofa
3.5.2.2 glutaric acid monoamide
-
 Sus scrofa
3.5.2.2 N-Carbamoyl-beta-alanine
-
 Sus scrofa
3.5.2.2 propionic acid
-
 Sus scrofa
3.5.2.2 propionic acid amide
-
 Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.2.2 54000
-
 4 * 54000, SDS-PAGE Sus scrofa
3.5.2.2 210000
-
-
 Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.2.2 5,6-dihydrouracil + H2O Sus scrofa
-
 3-ureidopropionate
-
 r
3.5.2.2 5,6-dihydrouracil + H2O Bos taurus
-
 3-ureidopropionate
-
 r
3.5.2.2 hydantoin + H2O Sus scrofa
-
 N-carbamoyl glycine
-
 ?
3.5.2.2 hydantoin + H2O Bos taurus
-
 N-carbamoyl glycine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.2.2 Bos taurus
-
 calf
-
3.5.2.2 Sus scrofa
-
 pig
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.2.2
-
 Sus scrofa
3.5.2.2
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.2.2 liver
-
 Sus scrofa
-
3.5.2.2 liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.2.2 1.06
-
-
 Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.2.2 5,6-dihydrouracil + H2O
-
 Sus scrofa 3-ureidopropionate
-
 r
3.5.2.2 5,6-dihydrouracil + H2O
-
 Bos taurus 3-ureidopropionate
-
 r
3.5.2.2 5-bromo-5,6-dihydrouracil + H2O
-
 Sus scrofa ?
-
 r
3.5.2.2 5-bromo-5,6-dihydrouracil + H2O
-
 Bos taurus ?
-
 r
3.5.2.2 glutarimide + H2O
-
 Sus scrofa ?
-
 ?
3.5.2.2 glutarimide + H2O
-
 Bos taurus ?
-
 ?
3.5.2.2 hydantoin + H2O
-
 Sus scrofa N-carbamoyl glycine
-
 ?
3.5.2.2 hydantoin + H2O
-
 Bos taurus N-carbamoyl glycine
-
 ?
3.5.2.2 N-carbamoyl beta-alanine + H2O
-
 Sus scrofa 5,6-dihydrouracil
-
 r
3.5.2.2 N-carbamoyl beta-alanine + H2O
-
 Bos taurus 5,6-dihydrouracil
-
 r

Subunits

EC Number Subunits Comment Organism
3.5.2.2 tetramer
-
 Bos taurus
3.5.2.2 tetramer 4 * 54000, SDS-PAGE Sus scrofa