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Literature summary extracted from

  • Sugimura, T.; Yamada, M.; Miwa, M.; Matsushima, T.; Hidaka, T.; Nagao, M.; Inui, N.; Takayama, S.
    Properties of poly(adenosine diphosphate ribose) polymerase, poly(adenosine diphosphate ribose) glycohydrolase and poly(adenosine diphosphate ribose) (1973), Biochem. Soc. Trans., 1, 642-644.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.2.1.143 2-mercaptoethanol enhances activity Bos taurus
3.2.1.143 dithiothreitol enhances activity Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.143 adenosine 3':5'-cyclic monophosphate
-
 Bos taurus
3.2.1.143 adenosine cyclic 2':3'-monophosphate
-
 Bos taurus
3.2.1.143 ADP
-
 Bos taurus
3.2.1.143 ADP-ribose
-
 Bos taurus
3.2.1.143 AMP
-
 Bos taurus
3.2.1.143 ATP
-
 Bos taurus
3.2.1.143 guanosine cyclic 3':5'-monophosphate
-
 Bos taurus
3.2.1.143 histone lysine-rich histone of calf thymus Bos taurus
3.2.1.143 NAD+
-
 Bos taurus
3.2.1.143 p-chloromercuribenzenesulfonate
-
 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.143 poly(ADP-ribose)n + H2O Bos taurus the enzyme may regulate functionally the chain length of poly(ADP-ribose) which plays a role in DNA synthesis or in the structure of chromatin ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.143 Bos taurus
-
 calf
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.143 thymus
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.143 poly(ADP-ribose)n + H2O
-
 Bos taurus ADP-ribose
-
 ?
3.2.1.143 poly(ADP-ribose)n + H2O the enzyme may regulate functionally the chain length of poly(ADP-ribose) which plays a role in DNA synthesis or in the structure of chromatin Bos taurus ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.1.143 7
-
-
 Bos taurus