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Literature summary extracted from
- S-Adenosylhomocysteine hydrolases as the primary target enzymes in androgen regulation of methylation complexes (1981), Arch. Biochem. Biophys., 208, 261-272.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.13.2.1 | 5alpha-dihydrotestosterone | stimulating and stabilizing, promotes formation of ternary complexes, restores specific activity after hypophysectomy | Rattus norvegicus |  |
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 3.13.2.1 | isozymes become unstable after DEAE-cellulose chromatography, ternary tRNA complexes are most stable form of enzymes, testosterone promotes formation of ternary complexes and prevents inactivation, hyperphysectomy leads to dissociation of ternary complexes and to loss of specific activity, stability of enzyme also improved by 5alpha-dihydrotestosterone | Rattus norvegicus |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.13.2.1 | 0.00033 | - |
adenosine | column-retained isozyme | Rattus norvegicus | |
| 3.13.2.1 | 0.00181 | - |
adenosine | flow-through isozyme | Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.13.2.1 | cytosol | - |
Rattus norvegicus | 5829 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.13.2.1 | S-adenosyl-L-homocysteine + H2O | Rattus norvegicus | - |
adenosine + L-homocysteine | - |
? | |
| 3.13.2.1 | S-adenosyl-L-homocysteine + H2O | Rattus norvegicus Sprague-Dawley | - |
adenosine + L-homocysteine | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.13.2.1 | Rattus norvegicus | - |
Sprague-Dawley | - |
| 3.13.2.1 | Rattus norvegicus Sprague-Dawley | - |
Sprague-Dawley | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.13.2.1 | to homogeneity | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.13.2.1 | Novikoff hepatoma cell | - |
Rattus norvegicus | - |
| 3.13.2.1 | prostate gland | - |
Rattus norvegicus | - |
| 3.13.2.1 | testis | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.13.2.1 | S-adenosyl-L-homocysteine + H2O | - |
Rattus norvegicus | adenosine + L-homocysteine | - |
? | |
| 3.13.2.1 | S-adenosyl-L-homocysteine + H2O | - |
Rattus norvegicus Sprague-Dawley | adenosine + L-homocysteine | - |
? | |
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Release 2023.1 (January 2023)
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