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Literature summary extracted from

  • Walker, R.D.; Duerre, J.A.
    S-Adenosylhomocysteine metabolism in various species (1975), Can. J. Biochem., 53, 312-319.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.13.2.1 adenine
-
 Rattus norvegicus
3.13.2.1 adenine
-
 Saccharomyces cerevisiae
3.13.2.1 adenosine
-
 Rattus norvegicus
3.13.2.1 L-homocysteine
-
 Rattus norvegicus
3.13.2.1 L-homocysteine
-
 Saccharomyces cerevisiae
3.13.2.1 S-adenosyl-L-homocysteine
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.13.2.1 1.5
-
 adenosine
-
 Rattus norvegicus
3.13.2.1 4.5
-
 L-homocysteine
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.2.9 5'-methylthioadenosine + H2O Staphylococcus aureus
-
 ?
-
 ?
3.2.2.9 5'-methylthioadenosine + H2O Alcaligenes faecalis
-
 ?
-
 ?
3.2.2.9 5'-methylthioadenosine + H2O Escherichia coli
-
 ?
-
 ?
3.2.2.9 5'-methylthioadenosine + H2O Klebsiella aerogenes
-
 ?
-
 ?
3.2.2.9 5'-methylthioadenosine + H2O Proteus vulgaris
-
 ?
-
 ?
3.2.2.9 5'-methylthioadenosine + H2O Citrobacter freundii
-
 ?
-
 ?
3.2.2.9 5'-methylthioadenosine + H2O Bacillus mycoides
-
 ?
-
 ?
3.2.2.9 5'-methylthioadenosine + H2O Escherichia coli W-ATCC 963
-
 ?
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O Staphylococcus aureus
-
 ?
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O Alcaligenes faecalis
-
 ?
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O Escherichia coli
-
 ?
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O Klebsiella aerogenes
-
 ?
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O Proteus vulgaris
-
 ?
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O Micrococcus luteus
-
 ?
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O Citrobacter freundii
-
 ?
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O Bacillus mycoides
-
 ?
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O Escherichia coli W-ATCC 963
-
 ?
-
 ?
3.13.2.1 S-adenosyl-L-homocysteine + H2O Gallus gallus
-
 adenosine + L-homocysteine
-
 r
3.13.2.1 S-adenosyl-L-homocysteine + H2O Phaseolus vulgaris
-
 adenosine + L-homocysteine
-
 r
3.13.2.1 S-adenosyl-L-homocysteine + H2O Cyberlindnera jadinii
-
 adenosine + L-homocysteine
-
 r
3.13.2.1 S-adenosyl-L-homocysteine + H2O Rattus norvegicus
-
 adenosine + L-homocysteine
-
 r
3.13.2.1 S-adenosyl-L-homocysteine + H2O Saccharomyces cerevisiae
-
 adenosine + L-homocysteine
-
 r
3.13.2.1 S-adenosyl-L-homocysteine + H2O Oryctolagus cuniculus
-
 adenosine + L-homocysteine
-
 r
3.13.2.1 S-adenosyl-L-homocysteine + H2O Spinacia oleracea
-
 adenosine + L-homocysteine
-
 r
3.13.2.1 S-adenosyl-L-homocysteine + H2O Zea mays
-
 adenosine + L-homocysteine
-
 r
3.13.2.1 S-adenosyl-L-homocysteine + H2O Canis lupus familiaris
-
 adenosine + L-homocysteine
-
 r
3.13.2.1 S-adenosyl-L-homocysteine + H2O Candida albicans
-
 adenosine + L-homocysteine
-
 r
3.13.2.1 S-adenosyl-L-homocysteine + H2O Hordeum vulgare subsp. vulgare
-
 adenosine + L-homocysteine
-
 r
3.13.2.1 S-adenosyl-L-homocysteine + H2O Rattus norvegicus Sprague-Dawley
-
 adenosine + L-homocysteine
-
 r

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.9 Alcaligenes faecalis
-
-
-
3.2.2.9 Bacillus mycoides
-
 var. cereus
-
3.2.2.9 Citrobacter freundii
-
-
-
3.2.2.9 Escherichia coli
-
-
-
3.2.2.9 Escherichia coli W-ATCC 963
-
-
-
3.2.2.9 Klebsiella aerogenes
-
-
-
3.2.2.9 Micrococcus luteus
-
-
-
3.2.2.9 Proteus vulgaris
-
-
-
3.2.2.9 Rattus rattus
-
 rat
-
3.2.2.9 Staphylococcus aureus
-
-
-
3.13.2.1 Candida albicans
-
-
-
3.13.2.1 Canis lupus familiaris
-
-
-
3.13.2.1 Cyberlindnera jadinii
-
-
-
3.13.2.1 Gallus gallus
-
 white leghorn
-
3.13.2.1 Hordeum vulgare subsp. vulgare
-
 barley
-
3.13.2.1 Oryctolagus cuniculus
-
-
-
3.13.2.1 Phaseolus vulgaris
-
 green bean
-
3.13.2.1 Rattus norvegicus
-
 Sprague-Dawley
-
3.13.2.1 Rattus norvegicus Sprague-Dawley
-
 Sprague-Dawley
-
3.13.2.1 Saccharomyces cerevisiae
-
-
-
3.13.2.1 Spinacia oleracea
-
 spinach
-
3.13.2.1 Zea mays
-
 field corn
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.2.2.9
-
 Escherichia coli
3.13.2.1
-
 Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
3.13.2.1 S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine Gallus gallus
a
3.13.2.1 S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine Phaseolus vulgaris
a
3.13.2.1 S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine Cyberlindnera jadinii
a
3.13.2.1 S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine Rattus norvegicus
a
3.13.2.1 S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine Saccharomyces cerevisiae
a
3.13.2.1 S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine Oryctolagus cuniculus
a
3.13.2.1 S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine Spinacia oleracea
a
3.13.2.1 S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine Zea mays
a
3.13.2.1 S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine Canis lupus familiaris
a
3.13.2.1 S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine Candida albicans
a
3.13.2.1 S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine Hordeum vulgare subsp. vulgare
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.13.2.1 brain very low level Gallus gallus
-
3.13.2.1 brain very low level Rattus norvegicus
-
3.13.2.1 brain very low level Oryctolagus cuniculus
-
3.13.2.1 brain very low level Canis lupus familiaris
-
3.13.2.1 heart very low level Gallus gallus
-
3.13.2.1 heart very low level Rattus norvegicus
-
3.13.2.1 heart very low level Oryctolagus cuniculus
-
3.13.2.1 heart very low level Canis lupus familiaris
-
3.13.2.1 kidney
-
 Gallus gallus
-
3.13.2.1 kidney
-
 Rattus norvegicus
-
3.13.2.1 kidney
-
 Oryctolagus cuniculus
-
3.13.2.1 kidney
-
 Canis lupus familiaris
-
3.13.2.1 leaf
-
 Phaseolus vulgaris
-
3.13.2.1 leaf
-
 Spinacia oleracea
-
3.13.2.1 liver
-
 Gallus gallus
-
3.13.2.1 liver
-
 Rattus norvegicus
-
3.13.2.1 liver
-
 Oryctolagus cuniculus
-
3.13.2.1 liver
-
 Canis lupus familiaris
-
3.13.2.1 pancreas
-
 Gallus gallus
-
3.13.2.1 pancreas
-
 Rattus norvegicus
-
3.13.2.1 pancreas
-
 Oryctolagus cuniculus
-
3.13.2.1 pancreas
-
 Canis lupus familiaris
-
3.13.2.1 seedling etiolated Phaseolus vulgaris
-
3.13.2.1 seedling etiolated Zea mays
-
3.13.2.1 seedling etiolated Hordeum vulgare subsp. vulgare
-
3.13.2.1 spleen low level Gallus gallus
-
3.13.2.1 spleen low level Rattus norvegicus
-
3.13.2.1 spleen low level Oryctolagus cuniculus
-
3.13.2.1 spleen low level Canis lupus familiaris
-
3.13.2.1 testis low level Gallus gallus
-
3.13.2.1 testis low level Rattus norvegicus
-
3.13.2.1 testis low level Oryctolagus cuniculus
-
3.13.2.1 testis low level Canis lupus familiaris
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.13.2.1 0.00003 0.0003 differs, depending on which organ is examined, hydrolysis of S-adenosyl-L-homocysteine, crude extract Canis lupus familiaris
3.13.2.1 0.00005 0.00036 differs, depending on which organ is examined, hydrolysis of S-adenosyl-L-homocysteine, crude extract Gallus gallus
3.13.2.1 0.00008 0.00091 differs, depending on which organ is examined, hydrolysis of S-adenosyl-L-homocysteine, crude extract Rattus norvegicus
3.13.2.1 0.00008 0.00092 differs, depending on which organ is examined, hydrolysis of S-adenosyl-L-homocysteine, crude extract Oryctolagus cuniculus
3.13.2.1 0.0027
-
 crude extract Spinacia oleracea
3.13.2.1 0.0031 0.09 differs, depending on which organ is examined, synthesis of S-adenosyl-L-homocysteine, crude extract Rattus norvegicus
3.13.2.1 0.0033 0.0259 differs, depending on which organ is examined, synthesis of S-adenosyl-L-homocysteine, crude extract Gallus gallus
3.13.2.1 0.0055 0.0588 differs, depending on which organ is examined, synthesis of S-adenosyl-L-homocysteine, crude extract Oryctolagus cuniculus
3.13.2.1 0.01
-
 crude extract Candida albicans
3.13.2.1 0.012
-
 crude extract Cyberlindnera jadinii
3.13.2.1 0.0127
-
 crude extract Phaseolus vulgaris
3.13.2.1 0.015
-
 crude extract Saccharomyces cerevisiae
3.13.2.1 0.0215
-
 crude extract Hordeum vulgare subsp. vulgare
3.13.2.1 0.0356
-
 up to this value, differs, depending on which organ is examined, synthesis of S-adenosyl-L-homocysteine, crude extract Canis lupus familiaris
3.13.2.1 0.0615
-
 crude extract Phaseolus vulgaris
3.13.2.1 0.0707
-
 crude extract Zea mays

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.2.9 5'-methylthioadenosine + H2O
-
 Staphylococcus aureus 5-methylthio-D-ribose + adenine
-
 ?
3.2.2.9 5'-methylthioadenosine + H2O
-
 Alcaligenes faecalis 5-methylthio-D-ribose + adenine
-
 ?
3.2.2.9 5'-methylthioadenosine + H2O
-
 Escherichia coli 5-methylthio-D-ribose + adenine
-
 ?
3.2.2.9 5'-methylthioadenosine + H2O
-
 Klebsiella aerogenes 5-methylthio-D-ribose + adenine
-
 ?
3.2.2.9 5'-methylthioadenosine + H2O
-
 Proteus vulgaris 5-methylthio-D-ribose + adenine
-
 ?
3.2.2.9 5'-methylthioadenosine + H2O
-
 Citrobacter freundii 5-methylthio-D-ribose + adenine
-
 ?
3.2.2.9 5'-methylthioadenosine + H2O
-
 Bacillus mycoides 5-methylthio-D-ribose + adenine
-
 ?
3.2.2.9 5'-methylthioadenosine + H2O
-
 Escherichia coli W-ATCC 963 5-methylthio-D-ribose + adenine
-
 ?
3.2.2.9 5'-methylthioadenosine + H2O
-
 Staphylococcus aureus ?
-
 ?
3.2.2.9 5'-methylthioadenosine + H2O
-
 Alcaligenes faecalis ?
-
 ?
3.2.2.9 5'-methylthioadenosine + H2O
-
 Escherichia coli ?
-
 ?
3.2.2.9 5'-methylthioadenosine + H2O
-
 Klebsiella aerogenes ?
-
 ?
3.2.2.9 5'-methylthioadenosine + H2O
-
 Proteus vulgaris ?
-
 ?
3.2.2.9 5'-methylthioadenosine + H2O
-
 Citrobacter freundii ?
-
 ?
3.2.2.9 5'-methylthioadenosine + H2O
-
 Bacillus mycoides ?
-
 ?
3.2.2.9 5'-methylthioadenosine + H2O
-
 Escherichia coli W-ATCC 963 ?
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O
-
 Staphylococcus aureus adenine + S-ribosyl-L-homocysteine
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O
-
 Alcaligenes faecalis adenine + S-ribosyl-L-homocysteine
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O
-
 Escherichia coli adenine + S-ribosyl-L-homocysteine
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O
-
 Klebsiella aerogenes adenine + S-ribosyl-L-homocysteine
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O
-
 Proteus vulgaris adenine + S-ribosyl-L-homocysteine
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O
-
 Micrococcus luteus adenine + S-ribosyl-L-homocysteine
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O
-
 Citrobacter freundii adenine + S-ribosyl-L-homocysteine
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O
-
 Bacillus mycoides adenine + S-ribosyl-L-homocysteine
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O
-
 Escherichia coli W-ATCC 963 adenine + S-ribosyl-L-homocysteine
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O
-
 Staphylococcus aureus ?
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O
-
 Alcaligenes faecalis ?
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O
-
 Escherichia coli ?
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O
-
 Klebsiella aerogenes ?
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O
-
 Proteus vulgaris ?
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O
-
 Micrococcus luteus ?
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O
-
 Citrobacter freundii ?
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O
-
 Bacillus mycoides ?
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O
-
 Escherichia coli W-ATCC 963 ?
-
 ?
3.13.2.1 S-adenosyl-L-homocysteine + H2O
-
 Gallus gallus adenosine + L-homocysteine
-
 r
3.13.2.1 S-adenosyl-L-homocysteine + H2O
-
 Phaseolus vulgaris adenosine + L-homocysteine
-
 r
3.13.2.1 S-adenosyl-L-homocysteine + H2O
-
 Cyberlindnera jadinii adenosine + L-homocysteine
-
 r
3.13.2.1 S-adenosyl-L-homocysteine + H2O
-
 Rattus norvegicus adenosine + L-homocysteine
-
 r
3.13.2.1 S-adenosyl-L-homocysteine + H2O
-
 Saccharomyces cerevisiae adenosine + L-homocysteine
-
 r
3.13.2.1 S-adenosyl-L-homocysteine + H2O
-
 Oryctolagus cuniculus adenosine + L-homocysteine
-
 r
3.13.2.1 S-adenosyl-L-homocysteine + H2O
-
 Spinacia oleracea adenosine + L-homocysteine
-
 r
3.13.2.1 S-adenosyl-L-homocysteine + H2O
-
 Zea mays adenosine + L-homocysteine
-
 r
3.13.2.1 S-adenosyl-L-homocysteine + H2O
-
 Canis lupus familiaris adenosine + L-homocysteine
-
 r
3.13.2.1 S-adenosyl-L-homocysteine + H2O
-
 Candida albicans adenosine + L-homocysteine
-
 r
3.13.2.1 S-adenosyl-L-homocysteine + H2O
-
 Hordeum vulgare subsp. vulgare adenosine + L-homocysteine
-
 r
3.13.2.1 S-adenosyl-L-homocysteine + H2O
-
 Rattus norvegicus Sprague-Dawley adenosine + L-homocysteine
-
 r

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.2.9 5.5 7
-
 Staphylococcus aureus
3.2.2.9 5.5 7
-
 Alcaligenes faecalis
3.2.2.9 5.5 7
-
 Escherichia coli
3.2.2.9 5.5 7
-
 Klebsiella aerogenes
3.2.2.9 5.5 7
-
 Proteus vulgaris
3.2.2.9 5.5 7
-
 Micrococcus luteus
3.2.2.9 5.5 7
-
 Citrobacter freundii
3.2.2.9 5.5 7
-
 Bacillus mycoides