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Literature summary extracted from

  • He, X.; Miranda, S.R.P.; Xiong, X.; Dagan, A.; Gatt, S.; Schuchman, E.H.
    Characterization of human acid sphingomyelinase purified from the media of overexpressing chinese hamster ovary cells (1999), Biochim. Biophys. Acta, 1432, 251-264.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.12 overexpressed in chinese hamster ovary cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.12 1,10-phenanthroline
-
 Homo sapiens
3.1.4.12 dithiothreitol
-
 Homo sapiens
3.1.4.12 mannose 6-phosphate Niemann-Pick disease fibroblasts Homo sapiens
3.1.4.12 sulphydryl reagents
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.12 Zn2+
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.4.12 60000
-
 1 * 75000 + 1 * 60000 Homo sapiens
3.1.4.12 75000
-
 1 * 75000 + 1 * 60000 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Homo sapiens
-
 Niemann-Pick disease patients
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.4.12 30fold Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 sphingomyelin + H2O
-
 Homo sapiens N-acylsphingosine + choline phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.4.12 dimer 1 * 75000 + 1 * 60000 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.4.12 37
-
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.12 4.5
-
-
 Homo sapiens