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Literature summary extracted from

  • Spence, M.W.; Byers, D.M.; Palmer, F.B.St.C.; Cook, H.W.
    A new Zn2+-stimulated sphingomyelinase in fetal bovine serum (1989), J. Biol. Chem., 264, 5358-5363.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.12 sodium deoxycholate
-
 Bos taurus
3.1.4.12 Triton X-100
-
 Homo sapiens
3.1.4.12 Triton X-100 stimulates up to 15fold Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.12 AMP
-
 Bos taurus
3.1.4.12 EDTA
-
 Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.12 Fe2+
-
 Bos taurus
3.1.4.12 Zn2+
-
 Homo sapiens
3.1.4.12 Zn2+
-
 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 sphingomyelin + H2O Homo sapiens
-
 ?
-
 ?
3.1.4.12 sphingomyelin + H2O Bos taurus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Bos taurus
-
-
-
3.1.4.12 Equus caballus
-
-
-
3.1.4.12 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 brain
-
 Homo sapiens
-
3.1.4.12 brain
-
 Bos taurus
-
3.1.4.12 liver
-
 Homo sapiens
-
3.1.4.12 liver
-
 Bos taurus
-
3.1.4.12 serum
-
 Equus caballus
-
3.1.4.12 serum fetal Bos taurus
-
3.1.4.12 serum newborn Bos taurus
-
3.1.4.12 serum from cord blood of infants of 30-40 weeks, of adults from normal healthy volunteers of either sex, from patients with Padgetis disease Homo sapiens
-

Storage Stability

EC Number Storage Stability Organism
3.1.4.12 -20°C, up to 1 year Homo sapiens
3.1.4.12 -20°C, up to 1 year Bos taurus
3.1.4.12 -20°C, up to 1 year Equus caballus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 sphingomyelin + H2O
-
 Homo sapiens N-acylsphingosine + choline phosphate
-
 ?
3.1.4.12 sphingomyelin + H2O
-
 Bos taurus N-acylsphingosine + choline phosphate
-
 ?
3.1.4.12 sphingomyelin + H2O
-
 Homo sapiens ?
-
 ?
3.1.4.12 sphingomyelin + H2O
-
 Bos taurus ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.4.12 37
-
-
 Homo sapiens
3.1.4.12 37
-
-
 Bos taurus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.1.4.12 55
-
 up to Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.12 5.5
-
-
 Homo sapiens
3.1.4.12 5.5
-
-
 Bos taurus