Literature summary extracted from

Ferone, R.; Warskow, A.
Co-purification of dihydrofolate synthetase and N-10formyltetrahydropteroyldiglutamate synthetase from E. coli (1983), Adv. Exp. Med. Biol., 163, 167-181.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
6.3.2.12	additional information	no inhibition by 10N-formyltetrahydropteroyldiglutamate	Escherichia coli

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
6.3.2.12	K+	monovalent cation required	Escherichia coli
6.3.2.12	K+	monovalent cation requirement is satisfied by K+, Rb+ or NH4+	Escherichia coli
6.3.2.12	NH4+	monovalent cation requirement is satisfied by K+, Rb+ or NH4+	Escherichia coli
6.3.2.12	Rb+	monovalent cation requirement is satisfied by K+, Rb+ or NH4+	Escherichia coli

Organism

EC Number	Organism	UniProt	Comment	Textmining
6.3.2.12	Escherichia coli	-	enzyme posseses dihydrofolate synthetase and N10-formyltetrahydropteroyldiglutamate synthetase activity	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
6.3.2.12	-	Escherichia coli

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6.3.2.12	ATP + 7,8-dihydropteroate + L-Glu	-	Escherichia coli	ADP + phosphate + 7,8-dihydrofolate	-	?

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Release 2023.1 (January 2023)