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Literature summary extracted from

  • Shane, B.
    Properties of Corynebacterium species dihydrofolate synthetase-folylpolyglutamate synthetase (1983), Chem. Biol. Pteridines, Proc. Int. Symp. Pteridines Folic Acid Deriv. Chem. Biol. Clin. Aspects, , 621-626.
No PubMed abstract available

General Stability

EC Number General Stability Organism
6.3.2.12 relatively stable to trypsin pretreatment and relatively large amounts of protease and a temperature of 37°C are required for digestion Corynebacterium sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.12 pABA
-
 Corynebacterium sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.2.12 0.0012
-
 7,8-dihydropteroate
-
 Corynebacterium sp.

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.2.12 K+ monovalent cation required, 200 mM K+ is most effective Corynebacterium sp.

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.12 Corynebacterium sp.
-
 enzyme posseses both dihydrofolate synthetase activity and folylpolyglutamate synthetase activity
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.12 ATP + 7,8-dihydropteroate + L-Glu
-
 Corynebacterium sp. ADP + phosphate + 7,8-dihydrofolate
-
 ?
6.3.2.12 dATP + 7,8-dihydropteroate + L-Glu 40.5% of the activity relative to ATP Corynebacterium sp. dADP + phosphate + 7,8-dihydrofolate
-
 ?
6.3.2.12 GTP + 7,8-dihydropteroate + L-Glu 11.0% of the activity relative to ATP Corynebacterium sp. GDP + phosphate + 7,8-dihydrofolate
-
 ?
6.3.2.12 ITP + 7,8-dihydropteroate + L-Glu 7.8% of the activity relative to ATP Corynebacterium sp. IDP + phosphate + 7,8-dihydrofolate
-
 ?
6.3.2.12 UTP + 7,8-dihydropteroate + L-Glu 79.8% of the activity relative to ATP Corynebacterium sp. UDP + phosphate + 7,8-dihydrofolate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3.2.12 10
-
-
 Corynebacterium sp.