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Literature summary for 7.6.2.1 extracted from
- Persistence of procoagulant surface expression on activated human platelets: involvement of apoptosis and aminophospholipid translocase activity (2007), J. Thromb. Haemost., 5, 560-570.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | - |
Homo sapiens | 5886 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the enzyme SCRM-1 catalyzes the externalization of phosphatidylserine to the cell surface. Activated platelets express a procoagulant surface when the asymmetric distribution of membrane phospholipids is scrambled, leading to phosphatidylserine exposure. Phosphatidylserine expression, associated with apoptosis in nucleated cells, is reversed by APLT activity. Persistence of procoagulant surface expression is due to reduced APLT activity, regulation, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood platelet | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme SCRM-1 catalyzes the externalization of phosphatidylserine to the cell surface. Activated platelets express a procoagulant surface when the asymmetric distribution of membrane phospholipids is scrambled, leading to phosphatidylserine exposure. Phosphatidylserine expression, associated with apoptosis in nucleated cells, is reversed by APLT activity. Persistence of procoagulant surface expression is due to reduced APLT activity, regulation, overview | Homo sapiens | ? | - |
? | |
| additional information | the enzyme SCRM-1 catalyzes the externalization of phosphatidylserine to the cell surface | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aminophospholipid translocase | - |
Homo sapiens |
| APLT | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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