Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 7.4.2.2 extracted from

  • Kaiser, J.; Omer, S.; Sheldon, J.; Welch, I.; Heinrichs, D.
    Role of BrnQ1 and BrnQ2 in branched-chain amino acid transport and virulence in Staphylococcus aureus (2015), Infect. Immun., 83, 1019-1029 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.4.2.2

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00093
-
 L-isoleucine-[L-isoleucine-binding protein][side 1] isoform BrnQ1, at 37°C, pH not specified in the publication Staphylococcus aureus
0.00162
-
 L-leucine-[L-leucine-binding protein][side 1] isoform BrnQ1, at 37°C, pH not specified in the publication Staphylococcus aureus
0.00179
-
 L-valine-[L-valine-binding protein][side 1] isoform BrnQ1, at 37°C, pH not specified in the publication Staphylococcus aureus
0.00894
-
 L-isoleucine-[L-isoleucine-binding protein][side 1] isoform BrnQ2, at 37°C, pH not specified in the publication Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + nonpolar amino acid-[nonpolar amino acid-binding protein][side 1] Staphylococcus aureus
-
 ADP + phosphate + nonpolar amino acid[side 2] + [nonpolar amino acid-binding protein][side 1]
-
 ?
ATP + H2O + nonpolar amino acid-[nonpolar amino acid-binding protein][side 1] Staphylococcus aureus USA300
-
 ADP + phosphate + nonpolar amino acid[side 2] + [nonpolar amino acid-binding protein][side 1]
-
 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-
Staphylococcus aureus USA300
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + L-isoleucine-[L-isoleucine-binding protein][side 1] substrate for isoforms BrnQ1 and BrnQ2 Staphylococcus aureus ADP + phosphate + L-isoleucine[side 2] + [L-isoleucine-binding protein][side 1]
-
 ?
ATP + H2O + L-isoleucine-[L-isoleucine-binding protein][side 1] substrate for isoforms BrnQ1 and BrnQ2 Staphylococcus aureus USA300 ADP + phosphate + L-isoleucine[side 2] + [L-isoleucine-binding protein][side 1]
-
 ?
ATP + H2O + L-leucine-[L-leucine-binding protein][side 1] substrate for isoform BrnQ1 Staphylococcus aureus ADP + phosphate + L-leucine[side 2] + [L-leucine-binding protein][side 1]
-
 ?
ATP + H2O + L-leucine-[L-leucine-binding protein][side 1] substrate for isoform BrnQ1 Staphylococcus aureus USA300 ADP + phosphate + L-leucine[side 2] + [L-leucine-binding protein][side 1]
-
 ?
ATP + H2O + L-valine-[L-valine-binding protein][side 1] substrate for isoform BrnQ1 Staphylococcus aureus ADP + phosphate + L-valine[side 2] + [L-valine-binding protein][side 1]
-
 ?
ATP + H2O + L-valine-[L-valine-binding protein][side 1] substrate for isoform BrnQ1 Staphylococcus aureus USA300 ADP + phosphate + L-valine[side 2] + [L-valine-binding protein][side 1]
-
 ?
ATP + H2O + nonpolar amino acid-[nonpolar amino acid-binding protein][side 1]
-
 Staphylococcus aureus ADP + phosphate + nonpolar amino acid[side 2] + [nonpolar amino acid-binding protein][side 1]
-
 ?
ATP + H2O + nonpolar amino acid-[nonpolar amino acid-binding protein][side 1]
-
 Staphylococcus aureus USA300 ADP + phosphate + nonpolar amino acid[side 2] + [nonpolar amino acid-binding protein][side 1]
-
 ?

Synonyms

Synonyms Comment Organism
BCAA transporter
-
 Staphylococcus aureus
branched-chain amino acid transporter
-
 Staphylococcus aureus
BrnQ1
-
 Staphylococcus aureus
BrnQ2
-
 Staphylococcus aureus

General Information

General Information Comment Organism
malfunction deletion of isoform BrnQ2 results in increased virulence, including severe kidney pathology Staphylococcus aureus
physiological function isoform BrnQ1 is required for Staphylococcus aureus strain USA300 fitness in vivo Staphylococcus aureus