Protein Variants | Comment | Organism |
---|---|---|
additional information | ctpA disruption mutants show a drastic decrease in both cbb3 and caa3 oxidase activities. Inactivation of ctpA results also in a decrease in the amount of the nitrous oxide reductase, NosZ. This pleiotropic phenotype can be partially rescued by excess copper in the medium | Rubrivivax gelatinosus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
inner membrane | - |
Bradyrhizobium japonicum | - |
- |
inner membrane | - |
Rhodobacter capsulatus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Bradyrhizobium japonicum | |
Mg2+ | required | Rubrivivax gelatinosus | |
Mg2+ | required | Rhodobacter capsulatus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Cu2+/in | Bradyrhizobium japonicum | - |
ADP + phosphate + Cu2+/out | - |
? | |
ATP + H2O + Cu2+/in | Rubrivivax gelatinosus | - |
ADP + phosphate + Cu2+/out | - |
? | |
ATP + H2O + Cu2+/in | Rhodobacter capsulatus | - |
ADP + phosphate + Cu2+/out | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bradyrhizobium japonicum | - |
gene ctpA or ccoI | - |
Rhodobacter capsulatus | - |
gene ctpA or ccoI | - |
Rubrivivax gelatinosus | - |
gene ctpA | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Cu2+/in | - |
Bradyrhizobium japonicum | ADP + phosphate + Cu2+/out | - |
? | |
ATP + H2O + Cu2+/in | - |
Rubrivivax gelatinosus | ADP + phosphate + Cu2+/out | - |
? | |
ATP + H2O + Cu2+/in | - |
Rhodobacter capsulatus | ADP + phosphate + Cu2+/out | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CcoI | - |
Bradyrhizobium japonicum |
CcoI | - |
Rhodobacter capsulatus |
copper-translocating P-type ATPase | - |
Bradyrhizobium japonicum |
copper-translocating P-type ATPase | - |
Rubrivivax gelatinosus |
copper-translocating P-type ATPase | - |
Rhodobacter capsulatus |
copper-translocating P1B-type ATPase | - |
Bradyrhizobium japonicum |
copper-translocating P1B-type ATPase | - |
Rhodobacter capsulatus |
CtpA | - |
Bradyrhizobium japonicum |
CtpA | - |
Rubrivivax gelatinosus |
CtpA | - |
Rhodobacter capsulatus |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is involved in the cbb3 assembly and in cbb3 oxidase biogenesis | Bradyrhizobium japonicum |
physiological function | the enzyme is involved in the cbb3 assembly and in cbb3 oxidase biogenesis | Rhodobacter capsulatus |
physiological function | the enzyme is involved only in the cbb3 assembly. CtpA is likely a copper transporter that supplies copper-requiring proteins in the membrane with this metal. Although CtpA shares significant sequence homologies with the homeostasis copper efflux P1B-type ATPases including the bacterial CopA and the human ATP7A and ATP7B, disruption of ctpA did not result in any sensitivity to excess copper. Thus, CtpA is not crucial for copper tolerance but is involved in the assembly of membrane and periplasmic copper enzymes in this bacterium | Rubrivivax gelatinosus |