Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 7.2.2.9 extracted from

  • Kuo, M.T.; Chen, H.H.; Song, I.S.; Savaraj, N.; Ishikawa, T.
    The roles of copper transporters in cisplatin resistance (2007), Cancer Metastasis Rev., 26, 71-83.
    View publication on PubMed
Search for more literature for 7.2.2.9

Application

Application Comment Organism
drug development review on transport mechanisms of platinum-based antitumor agents Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Cu2+/in Homo sapiens
-
 ADP + phosphate + Cu2+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P35670
-
-
Homo sapiens Q04656
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 discussion on identification of copper transporters ATP7A and ATP7B as platinum drug transporters, structural, functional and mechanistic aspects summarized, future research directions improving efficacy of platinum-based-based drugs in cancer chemotherapy through modulation of their transporter activities summarized Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cu2+/in
-
 Homo sapiens ADP + phosphate + Cu2+/out
-
 ?
ATP + H2O + Cu2+/in involvement of ATP7A and ATP7B in transport of platinum-based antitumor agents Homo sapiens ADP + phosphate + Cu2+/out
-
 ?
ATP + H2O + Cu2+/in involvement of ATP7A and ATP7B in transport of platinum-based antitumor agents reviewed Homo sapiens ADP + phosphate + Cu2+/out
-
 ?

Synonyms

Synonyms Comment Organism
ATP7A
-
 Homo sapiens
ATP7B
-
 Homo sapiens