Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Insulin | increase of mRNA and protein levels of ATP7A | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | studies on copper deficiency during pregnancy, Menkes and Wilson disease | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
membrane | basolateral membrane | Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Cu2+/in | Homo sapiens | - |
ADP + phosphate + Cu2+/out | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P35670 | - |
- |
Homo sapiens | Q04656 | ATP7A | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
JEG-3 cell | - |
Homo sapiens | - |
placenta | - |
Homo sapiens | - |
syncytiotrophoblast | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
effect of hormone treatment on expression analyzed by Western blot, indirect immunocytochemistry and real-time PCR, copper transport and accumulation, insulin and oestrogen increase ATP7A mRNA and protein levels and alter the localization of ATP7A towards the basolateral membrane in a copper-independent manner, insulin and oestrogen increase the transport of copper across basolateral membrane, model of insulin and oestrogen effect on ATP7A and ATP7B in the placenta | Homo sapiens |
additional information | - |
effect of hormone treatment on expression analyzed by Western blot, indirect immunocytochemistry and real-time PCR, copper transport and accumulation, levels of ATP7B decreased in response to insulin, protein shown to localize in a tight perinuclear region, corresponding decrease in copper efflux across the apical membrane, model of insulin and oestrogen effect on ATP7A and ATP7B in the human placenta | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Cu2+/in | - |
Homo sapiens | ADP + phosphate + Cu2+/out | - |
? | |
ATP + H2O + Cu2+/in | differential regulation of ATP7A and ATP7B by the hormones insulin and oestrogen in human placental cells | Homo sapiens | ADP + phosphate + Cu2+/out | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ATP7A | - |
Homo sapiens |
ATP7B | - |
Homo sapiens |
Menkes copper-transporting ATPase | - |
Homo sapiens |
MNK protein | - |
Homo sapiens |
Wilson copper-transporting ATPase | - |
Homo sapiens |
WND protein | - |
Homo sapiens |