Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | basolateral membrane of mammary epithelial cells in lactating mice | Mus musculus | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Cu2+/in | Mus musculus | - |
ADP + phosphate + Cu2+/out | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q64430 | ATP7A | - |
Mus musculus | Q64446 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mammary epithelium | ATP7A expressed in | Mus musculus | - |
mammary gland | ATP7A protein 10fold to 20fold higher in transgenic than in control mice | Mus musculus | - |
mammary gland | transgenic mice | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
copper concentration in the mammary gland reduced in transgenic mice, immunofluorescence analysis of mammary gland tissue, tissue copper concentration, mRNA levels of endogenous ATP7A and ATP7B and of ATP7B protein unaltered in mammary gland of transgenic mice, ATP7A plays a role in removing excess copper from mammary epithelial cells rather than supplying copper to milk | Mus musculus |
additional information | - |
mRNA levels of endogenous ATP7B and of ATP7B protein unaltered in mammary gland of transgenic mice | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Cu2+/in | - |
Mus musculus | ADP + phosphate + Cu2+/out | - |
? | |
ATP + H2O + Cu2+/in | role of ATP7A in delivery of copper to milk using transgenic mice that over-express human ATP7A | Mus musculus | ADP + phosphate + Cu2+/out | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ATP7A | - |
Mus musculus |
ATP7B | - |
Mus musculus |