Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endosome | mainly localized in the late endosomes in both the steady and copper-loaded states. ATP7B translocates copper from the cytosol to the late endosomal lumen, thus participating in biliary copper excretion via lysosomes | Homo sapiens | 5768 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Cu2+/in | Homo sapiens | ATP7B translocates copper from the cytosol to the late endosomal lumen, thus participating in biliary copper excretion via lysosomes. Disturbed incorporation of copper into the late endosomal lumen from the cytosol by the mutated ATP7B is the main defect of Wilson's disease | ADP + phosphate + Cu2+/out | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Cu2+/in | - |
Homo sapiens | ADP + phosphate + Cu2+/out | - |
? | |
ATP + H2O + Cu2+/in | ATP7B translocates copper from the cytosol to the late endosomal lumen, thus participating in biliary copper excretion via lysosomes. Disturbed incorporation of copper into the late endosomal lumen from the cytosol by the mutated ATP7B is the main defect of Wilson's disease | Homo sapiens | ADP + phosphate + Cu2+/out | - |
? |