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Literature summary for 7.2.2.14 extracted from

  • Ford, D.C.; Joshua, G.W.; Wren, B.W.; Oyston, P.C.
    The importance of the magnesium transporter MgtB for virulence of Yersinia pseudotuberculosis and Yersinia pestis (2014), Microbiology, 160, 2710-2717.
    View publication on PubMed
Search for more literature for 7.2.2.14

Organism

Organism UniProt Comment Textmining
Yersinia pestis Q7CIZ1
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Yersinia pseudotuberculosis
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Synonyms

Synonyms Comment Organism
MgtB
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 Yersinia pseudotuberculosis
MgtB
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 Yersinia pestis

General Information

General Information Comment Organism
physiological function inactivation of magnesium transporter MgtB leads to a reduced growth relative to the wild-type, even in media supplemented with 1 mM Mg2+. MgtB mutants survive equally as well as the respective parent strain within macrophages, although they are more sensitive to killing in the Galleria model of infection. MgtB is required for macrophage invasion in Yersinia pestis. Yersinia MgtB deletion mutants are more highly attenuated than the equivalent Yersinia PhoP two-component regulatory system deletion mutants in mouse models of infection Yersinia pestis
physiological function inactivation of magnesium transporter MgtB leads to a reduced growth relative to the wild-type, even in media supplemented with 1 mM Mg2+. MgtB mutants survive equally as well as the respective parent strain within macrophages, although they are more sensitive to killing in the Galleria model of infection. Yersinia MgtB deletion mutants are more highly attenuated than the equivalent Yersinia PhoP two-component regulatory system deletion mutants in mouse models of infection Yersinia pseudotuberculosis