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Literature summary for 7.2.2.13 extracted from

  • Berret, E.; Nehme, B.; Henry, M.; Toth, K.; Drolet, G.; Mouginot, D.
    Regulation of central Na+ detection requires the cooperative action of the NaX channel and alpha1 isoform of Na+/K+-ATPase in the Na+-sensor neuronal population (2013), J. Neurosci., 33, 3067-3078.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.13

Inhibitors

Inhibitors Comment Organism Structure
cinobufotalin 27.5% inhibition at 0.01 mM Rattus norvegicus
Ouabain 6.1% inhibition at 0.01 mM Rattus norvegicus
strophanthidin 29.6% inhibition at 0.01 mM Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Na+/in + K+/out Rattus norvegicus
-
 ADP + phosphate + Na+/out + K+/in
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuron
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Na+/in + K+/out
-
 Rattus norvegicus ADP + phosphate + Na+/out + K+/in
-
 ?

Synonyms

Synonyms Comment Organism
Na+,K+-ATPase
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function the Na+/K+-ATPase-alpha1 isoform is specifically involved in detection of extracellular Na+ concentration Rattus norvegicus