Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ethanol | inhibits the enzyme in Golgi membranes of cerebellar neurons leading to potentiation of GABAergic transmission at Golgi cell-to-granule cell synapses throughan increase in Golgi cell excitability | Rattus norvegicus | |
Ouabain | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi membrane | - |
Rattus norvegicus | 139 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Na+/in + K+/out | Rattus norvegicus | modelling of enzyme function in neurons in absence or presence of ethanol, overview | ADP + phosphate + Na+/out + K+/in | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Spargue-Dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cerebellum | - |
Rattus norvegicus | - |
granule cell | of the input layer of cerebellar cortex | Rattus norvegicus | - |
neuron | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Na+/in + K+/out | - |
Rattus norvegicus | ADP + phosphate + Na+/out + K+/in | - |
? | |
ATP + H2O + Na+/in + K+/out | modelling of enzyme function in neurons in absence or presence of ethanol, overview | Rattus norvegicus | ADP + phosphate + Na+/out + K+/in | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Na+/K+ ATPase | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
additional information | ethanol-induced Na+,K+-ATPase inhibition leads to cerebellar dysfunction causing motor coordination impairments and cognitive deficits, and may also contribute to neuronal function alterations in other brain regions, overview. Ethanol increases firing frequency and regularity of spontaneous firing in presence of neurotransmitter receptor antagonists, ethanol increases spontaneous firing frequency and depolarizes the membrane potential, overview | Rattus norvegicus |