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Literature summary for 7.2.2.13 extracted from

  • Liu, Y.; Yang, J.; Ren, H.; He, D.; Pascua, A.; Armando, M.I.; Yang, C.; Zhou, L.; Felder, R.A.; Jose, P.A.; Zeng, C.
    Inhibitory effect of ETB receptor on Na+-K+ ATPase activity by extracellular Ca(2+) entry and Ca(2+) release from the endoplasmic reticulum in renal proximal tubule cells (2009), Hypertens. Res., 32, 846-852.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.13

Inhibitors

Inhibitors Comment Organism Structure
BAY-K8644 a calcium channel agonist, the effect is blocked by a phosphatidylinositol-3 kinase inhibitor wortmannin Homo sapiens
BAY-K8644 a calcium channel agonist, the effect is blocked by a phosphatidylinositol-3 kinase inhibitor wortmannin Rattus norvegicus
additional information ETB receptor inhibits Na+-K+ ATPase activity by facilitating extracellular Ca2+ entry and Ca2+ release from endoplasmic reticulum Homo sapiens
additional information ETB receptor inhibits Na+-K+ ATPase activity by facilitating extracellular Ca2+ entry and Ca2+ release from endoplasmic reticulum Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-
membrane
-
 Rattus norvegicus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens
Mg2+ required Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Na+/in + K+/out Homo sapiens
-
 ADP + phosphate + Na+/out + K+/in
-
 ?
ATP + H2O + Na+/in + K+/out Rattus norvegicus
-
 ADP + phosphate + Na+/out + K+/in
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
 Wistar-Kyoto rats
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Rattus norvegicus
-
kidney from normotensive patients who have unilateral nephrectomy because of renal carcinoma or trauma Homo sapiens
-
proximal tubule
-
 Homo sapiens
-
proximal tubule
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Na+/in + K+/out
-
 Homo sapiens ADP + phosphate + Na+/out + K+/in
-
 ?
ATP + H2O + Na+/in + K+/out
-
 Rattus norvegicus ADP + phosphate + Na+/out + K+/in
-
 ?

Synonyms

Synonyms Comment Organism
Na+-K+ ATPase
-
 Homo sapiens
Na+-K+ ATPase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens
7.4
-
 assay at Rattus norvegicus

General Information

General Information Comment Organism
additional information ETB receptor inhibits Na+-K+ ATPase activity by facilitating extracellular Ca2+ entry and Ca2+ release from endoplasmic reticulum. The inhibitory effect is abolished by chelator of intracellular-free calcium BAPTA-AM, Ca2+ channel blocker nicardipine, inositol 1,4,5-trisphosphate receptor blocker 2-aminoethyl diphenyl borate, and PI3 kinase inhibitor wortmannin, overview Homo sapiens
additional information ETB receptor inhibits Na+-K+ ATPase activity by facilitating extracellular Ca2+ entry and Ca2+ release from endoplasmic reticulum. The inhibitory effect is abolished by chelator of intracellular-free calcium BAPTA-AM, Ca2+ channel blocker nicardipine, inositol 1,4,5-trisphosphate receptor blocker 2-aminoethyl diphenyl borate, and PI3 kinase inhibitor wortmannin, overview Rattus norvegicus